Contemporary Drug Synthesis

Author: Jie Jack Li
Editor: John Wiley & Sons
ISBN: 9780471686736
Size: 17,31 MB
Format: PDF
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An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Innovative Drug Synthesis

Author: Jie Jack Li
Editor: John Wiley & Sons
ISBN: 1118820088
Size: 13,26 MB
Format: PDF, ePub, Mobi
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This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

The Art Of Drug Synthesis

Author: Douglas S. Johnson
Editor: John Wiley & Sons
ISBN: 111867846X
Size: 16,88 MB
Format: PDF, ePub
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The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Modern Drug Synthesis

Author: Jie Jack Li
Editor: John Wiley & Sons
ISBN: 1118701240
Size: 15,57 MB
Format: PDF, Kindle
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Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

Drug Synthesis Book Set

Author:
Editor: John Wiley & Sons
ISBN: 9781119185659
Size: 18,83 MB
Format: PDF
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De Novo Synthese Trifluormethylierter Heterozyklen

Author: Thomas Wesch
Editor: Logos Verlag Berlin GmbH
ISBN: 3832528784
Size: 18,55 MB
Format: PDF
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Eine der wichtigsten Anwendungen fluororganischer Verbindungen ist in der Medizinischen Chemie zu finden. Durch Einfuhrung eines Fluor-Atoms in einen Wirkstoff konnen sowohl die Stabilitat als auch die Bioverfugbarkeit betrachtlich beeinflusst werden. Da bisher nur wenige naturlich vorkommende Fluorverbindungen isoliert werden konnten, ist die Entwicklung neuer Fluorierungsmethoden sehr wichtig, um somit den Zugang zu fluorhaltigen Substanzen zu eroffnen . In der vorliegenden Arbeit wird die de novo-Synthese trifluormethylierter Heterozyklen ausgehend von Trifluormethyl-substituierten 1,3-Diketonen und Enaminen vorgestellt. Die hier beschriebene Methode ermoglicht es, auf einfache Weissse trifluormethylierte Heterozyklen darzustellen, ohne entsprechende funktionelle-Gruppen unter zumeist harschen Bedingungen mittels Fluorierungsreagenzien zu transformieren. Je nach eingesetztem 1,3-Diketon oder Enamin konnte der Zugang zu einer Vielzahl an Substitutionsmustern und heterozyklischen Grundgerusten wie den Pyrrolopyridine, Pyrazolopyridine und Pyridine eroffnet werden.

Heterocyclic Chemistry In Drug Discovery

Author: Jie Jack Li
Editor: John Wiley & Sons
ISBN: 1118354435
Size: 16,51 MB
Format: PDF, ePub
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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Drug Discovery

Author: Jie Jack Li
Editor: John Wiley & Sons
ISBN: 111835446X
Size: 13,83 MB
Format: PDF
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Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.

Strategies For Organic Drug Synthesis And Design

Author: Daniel Lednicer
Editor: John Wiley & Sons
ISBN: 9780470399590
Size: 18,92 MB
Format: PDF, Kindle
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This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Pharmaceutical Substances 5th Edition 2009

Author: A. Kleemann
Editor: Georg Thieme Verlag
ISBN: 3131795255
Size: 14,53 MB
Format: PDF, ePub
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"Pharmaceutical Substances" is a compendium of 1,300 of the most significant pharmaceutical compounds that are of interest to the chemical and pharmaceutical industries. It is the ideal companion to the "Pharmaceutical Substances Online Edition" and an authoritative resource for everyone involved in design, discovery, development, evaluation, and marketing of drugs. Profs. Axel Kleemann, Jürgen Engel, Bernhard Kutscher, and Dr. Dietmar Reichert present in a clear and concise manner highly evaluated information collected from all the relevant literature, and commercial patent data. This includes synthetic routes and all intermediates for approved drugs from the six most important markets. All compounds are organized alphabetically according to their International Non-proprietary Name (INN). The book features four indexes: Trade Names / Intermediates / Enzymes, Microorganisms, Plants, and Animal Tissues / Substance Classes. // The content of this e-book was originally published in 2009.