Handbook Of Acute Leukemia

Author: Wolfgang Hiddemann
Editor: Springer
ISBN: 3319267728
Size: 11,31 MB
Format: PDF, ePub, Mobi
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This book provides an overview of the key developments in both acute lymphocytic leukemia and acute myeloid leukemia with a comprehensive guide to the epidemiology, pathogenesis, etiology, clinical manifestations, classification, diagnosis, and staging as well as the most recent developments in the therapeutic landscape for acute leukemia. The Handbook of Acute Leukemia offers readers a key resource into the future outlook for patients with leukemia and is edited and authored by internationally renowned experts in the field. Leukemia is cancer of the white blood cells and acute leukemia means the condition progresses rapidly and aggressively, requiring immediate treatment. Acute leukemia is classified according to the type of white blood cells that are affected: either lymphocytes and myeloid cells.

Targeted Therapy Of Acute Myeloid Leukemia

Author: Michael Andreeff
Editor: Springer
ISBN: 149391393X
Size: 10,77 MB
Format: PDF, ePub
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This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.

Neoplastic Diseases Of The Blood

Author: Peter H. Wiernik
Editor: Springer Science & Business Media
ISBN: 1461437644
Size: 17,89 MB
Format: PDF
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Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.

Cancer In Adolescents And Young Adults

Author: Archie Bleyer
Editor: Springer
ISBN: 3319336797
Size: 12,93 MB
Format: PDF, ePub, Docs
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This is the second edition of the only book to be devoted exclusively to the total cancer picture in adolescents and young adults (AYA), now expanded from the age range 15-29 to that of 15–39 years. For each of the diverse spectrum of cancers encountered in the AYA group, the epidemiology, natural progression, diagnostic approaches, and treatment options are described, with special emphasis on strategies for early detection and prevention. Comparison is made with management of both younger and older patients, and model programs are presented that address common diagnostic, staging, treatment, and psychosocial shortcomings in the AYA group. Detailed attention is also paid to principles and practices of care, with consideration of psychosocial and quality of life issues, social support systems, rehabilitation, late effects, insurance, and economic aspects of health care, among other topics. The authors make compelling arguments for integrated strategies that allow young adults to benefit from the combined expertise of pediatric and adult oncologists in systems that identify both the complex disease and the social issues specific to this population. The proposed models of care include relationships with other specialties that do not specifically target this age group, i.e., infectious disease, endocrinology, pulmonary medicine, nephrology, gastroenterology, thoracic and abdominal surgery, urology, otolaryngology, and neurosurgery. New patterns of communication are advocated and endorsed as essential for productive interaction involving these specialties. References are extensive and are oriented toward users in pediatric hematology-oncologymedical oncology, radiation oncology, surgical oncology, gynecologic oncology, oncology nursing, psycho-oncology, social work, epidemiology, public health and health services research. The contributing authors are from the United States, the United Kingdom, Canada, Italy, France, Israel, Switzerland and Australia, Germany, Japan and the Netherlands.p>

Hematologic Malignancies Acute Leukemias

Author: S.H. Faderl
Editor: Springer Science & Business Media
ISBN: 3540723048
Size: 12,67 MB
Format: PDF, Kindle
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Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Acute Promyelitic Leukemia

Author: Pier Paolo Pandolfi
Editor: Springer Science & Business Media
ISBN: 3540345949
Size: 19,86 MB
Format: PDF, Kindle
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Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.

Catalina

Author: Liska Jacobs
Editor: FSG Originals
ISBN: 0374716722
Size: 15,32 MB
Format: PDF
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A magnetic, provocative debut novel chronicling a young woman’s downward spiral following the end of an affair Elsa Fisher is headed for rock bottom. At least, that’s her plan. She has just been fired from MoMA on the heels of an affair with her married boss, and she retreats to Los Angeles to blow her severance package on whatever it takes to numb the pain. Her abandoned crew of college friends (childhood friend Charlotte and her wayward husband, Jared; and Elsa’s ex-husband, Robby) receive her with open arms, and, thinking she’s on vacation, a plan to celebrate their reunion on a booze-soaked sailing trip to Catalina Island. But Elsa doesn’t want to celebrate. She is lost, lonely, and full of rage, and only wants to sink as low as the drugs and alcohol will take her. On Catalina, her determined unraveling and recklessness expose painful memories and dark desires, putting everyone in the group at risk. With the creeping menace of Patricia Highsmith and the bender-chic of Bret Easton Ellis, Liska Jacobs brings you inside the mind of an angry, reckless young woman hell-bent on destruction—every page taut with the knowledge that Elsa’s path does not lead to a happy place. Catalina is a compulsive, deliciously dark exploration of beauty, love, and friendship, and the sometimes toxic desires that drive us.

Perioperative Hemostasis

Author: Carlo Marcucci
Editor: Springer
ISBN: 3642550045
Size: 17,36 MB
Format: PDF, Mobi
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All anesthesiologists are confronted with patients who show bleeding disorders, whether congenital, acquired, or pharmacologically induced. Although many studies, meta-analyses, guidelines, and textbooks have been published on the subject, they mostly cover specific aspects or require a thorough knowledge of hemostasis. The goal of this book is to provide the anesthesiologist with an overview of hemostasis and the mechanisms underlying bleeding and coagulation in general and to assist in the understanding of specific coagulation disorders as they may occur in the various anesthesia subspecialties. It is hoped that, through the provision of practical information and tools, the book will help residents and trained anesthesiologists to manage one of the most frustrating challenges that they face: the bleeding patient. A full understanding of coagulation requires a lifelong career, and this book is not intended to replace the consulting hematologist, whose expert opinion should always be sought. The available procoagulant blood products and drugs all have potentially dangerous side-effects; furthermore, in bleeding disorders pitfalls are frequent and a misdiagnosis can have potentially catastrophic consequences. The aim of the editors is thus instead to enhance the collaboration between the disciplines of Anesthesiology and Hematology.

Prognosis In Advanced Cancer

Author: Paul Glare
Editor: Oxford University Press
ISBN: 9780198530220
Size: 16,61 MB
Format: PDF
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Predicting survival and other outcomes is increasingly being recognized as an important skill for palliative care physicians, internists, and other health care professionals who care for patients with advanced cancer at the end of life. There is much prognostic information available that is scattered throughout the palliative care and oncological literature but this is the first time it has been gathered systematically in one place. This bookhas 36 chapters divided into three sections. The first is an introductory section that deals with the principles of prognostication, including formulating the prediction and then communicating it. Topics such as statistical issues, evidence based medicine, and the ethics of prognostication are alsocovered. The second section addresses prognostication in fifteen specific cancers when they have reached the advanced stage. The third section deals with prognostication in patients with a variety of common clinical conditions at the end of life, such as bowel obstruction, hypercalcemia, and brain metastases.

Calcium And Bone Disorders In Children And Adolescents

Author: J. Allgrove
Editor: Karger Medical and Scientific Publishers
ISBN: 3318054674
Size: 15,91 MB
Format: PDF, ePub, Docs
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There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including a chapter of case histories illustrating clinical aspects. New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced with a child with a calcium and/or bone disorder.