Evolutionary Arguments On Aging Disease And Other Topicsn Aging

Autore: Giacinto Libertini
Editore: Azinet
ISBN: 0978870921
Grandezza: 21,76 MB
Formato: PDF
Vista: 5453
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Every character of a living being has its function: the teeth are there to chew, the lungs to breathe, the eyes to see, etc. But what is the function of aging, if there even is one?If it is true that the living being is modelled by natural selection, what are the evolutionary needs that bring about limited longevity or variable longevity according to the species? Why does a mouse live less than two years, a tortoise many tens of years and Pinus Aristata not seem to age at all? Are these differences casual or is evolution somehow at the origin of it all, as A. Weismann hypothesized back in the last century?The results are beyond all expectations: it is possible to provide an explanation for the "why of senescence in evolutionary terms.Another important topic is the meaning of disease phenomenon in the context of evolutionary theory. Illness is a set of phenomena that is perfectly anticipated and rationally classifiable by evolutionary theory.This book, printed in Italian in 1983, broached these and other questions with a rigorous evolutionary approach, using mathematical models in its arguments for the graphic expression and the confirmation of the models.

Evolutionary Interpretations Of Aging Disease Phenomenon And Sex

Autore: Giacinto Libertini
Editore: Copernican editions
ISBN: 8890648600
Grandezza: 18,39 MB
Formato: PDF, Kindle
Vista: 2075
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Aging And Health A Systems Biology Perspective

Autore: A.I. Yashin
Editore: Karger Medical and Scientific Publishers
ISBN: 3318027308
Grandezza: 50,96 MB
Formato: PDF, ePub, Docs
Vista: 4105
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Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.

Evolution In Health And Disease

Autore: Stephen C. Stearns
Editore: Oxford University Press
ISBN: 0199207453
Grandezza: 36,61 MB
Formato: PDF, ePub, Docs
Vista: 3721
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A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.

How Men Age

Autore: Richard G. Bribiescas
Editore: Princeton University Press
ISBN: 1400883261
Grandezza: 14,68 MB
Formato: PDF, Docs
Vista: 2631
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While the health of aging men has been a focus of biomedical research for years, evolutionary biology has not been part of the conversation—until now. How Men Age is the first book to explore how natural selection has shaped male aging, how evolutionary theory can inform our understanding of male health and well-being, and how older men may have contributed to the evolution of some of the very traits that make us human. In this informative and entertaining book, renowned biological anthropologist Richard Bribiescas looks at all aspects of male aging through an evolutionary lens. He describes how the challenges males faced in their evolutionary past influenced how they age today, and shows how this unique evolutionary history helps explain common aspects of male aging such as prostate disease, loss of muscle mass, changes in testosterone levels, increases in fat, erectile dysfunction, baldness, and shorter life spans than women. Bribiescas reveals how many of the physical and behavioral changes that we negatively associate with male aging may have actually facilitated the emergence of positive traits that have helped make humans so successful as a species, including parenting, long life spans, and high fertility. Popular science at its most compelling, How Men Age provides new perspectives on the aging process in men and how we became human, and also explores future challenges for human evolution—and the important role older men might play in them.

Ending Aging

Autore: Aubrey de Grey
Editore: Macmillan
ISBN: 9781429931830
Grandezza: 12,28 MB
Formato: PDF, Kindle
Vista: 8607
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MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

Cancer Autism And Their Epigenetic Roots

Autore: K. John Morrow, Jr.
Editore: McFarland
ISBN: 0786479205
Grandezza: 10,30 MB
Formato: PDF
Vista: 8484
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This book considers the branch of heredity known as "epigenetics" and its implications for a variety of diseases in humans and animals. After background information on the growth in understanding genetics and the mechanisms of the epigenetic control of gene expression, the book moves into its main focus: the gathering body of evidence connecting genetics to a range of significant illnesses, including cancer, autism, Alzheimer's disease, diabetes and others. Areas of uncertainty are stressed as well as the scientific debate concerning the role of environmental factors. The final chapters discuss the implications for society. Extensive notes provide additional details and personal anecdotes.

Ageing Evidence

Autore:
Editore: The Stationery Office
ISBN: 9780104007280
Grandezza: 75,93 MB
Formato: PDF, Kindle
Vista: 3255
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Oxygen

Autore: Nick Lane
Editore: Oxford University Press, USA
ISBN: 9780198607830
Grandezza: 59,31 MB
Formato: PDF, ePub, Mobi
Vista: 7777
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Oxygen takes the reader on an enthralling journey, as gripping as a thriller, as it unravels the unexpected ways in which oxygen spurred the evolution of life and death. The book explains far more than the size of ancient insects: it shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated ageing of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it.

Cell Aging Molecular Mechanisms And Implications For Disease

Autore: Christian Behl
Editore: Springer Science & Business Media
ISBN: 3642451799
Grandezza: 22,20 MB
Formato: PDF, ePub
Vista: 1330
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Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.