Evolutionary Arguments On Aging Disease And Other Topicsn Aging

Autore: Giacinto Libertini
Editore: Azinet
ISBN: 0978870921
Grandezza: 59,30 MB
Formato: PDF, ePub, Mobi
Vista: 1346
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Every character of a living being has its function: the teeth are there to chew, the lungs to breathe, the eyes to see, etc. But what is the function of aging, if there even is one?If it is true that the living being is modelled by natural selection, what are the evolutionary needs that bring about limited longevity or variable longevity according to the species? Why does a mouse live less than two years, a tortoise many tens of years and Pinus Aristata not seem to age at all? Are these differences casual or is evolution somehow at the origin of it all, as A. Weismann hypothesized back in the last century?The results are beyond all expectations: it is possible to provide an explanation for the "why of senescence in evolutionary terms.Another important topic is the meaning of disease phenomenon in the context of evolutionary theory. Illness is a set of phenomena that is perfectly anticipated and rationally classifiable by evolutionary theory.This book, printed in Italian in 1983, broached these and other questions with a rigorous evolutionary approach, using mathematical models in its arguments for the graphic expression and the confirmation of the models.

Evolutionary Interpretations Of Aging Disease Phenomenon And Sex

Autore: Giacinto Libertini
Editore: Copernican editions
ISBN: 8890648600
Grandezza: 27,76 MB
Formato: PDF, ePub, Docs
Vista: 1688
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Cell Aging Molecular Mechanisms And Implications For Disease

Autore: Christian Behl
Editore: Springer Science & Business Media
ISBN: 3642451799
Grandezza: 35,87 MB
Formato: PDF, Docs
Vista: 8526
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Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Genetics And Evolution Of Aging

Autore: Michael R. Rose
Editore: Springer Science & Business Media
ISBN: 9401716714
Grandezza: 80,20 MB
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Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. © 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

Evolution In Health And Disease

Autore: Stephen C. Stearns
Editore: Oxford University Press
ISBN: 0199207453
Grandezza: 47,15 MB
Formato: PDF
Vista: 5869
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A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.

The Biology Of Human Longevity

Autore: Caleb E. Finch
Editore: Academic Press
ISBN: 9780080545943
Grandezza: 68,28 MB
Formato: PDF, Kindle
Vista: 9165
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Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

How Men Age

Autore: Richard G. Bribiescas
Editore: Princeton University Press
ISBN: 1400883261
Grandezza: 67,17 MB
Formato: PDF, Kindle
Vista: 4745
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While the health of aging men has been a focus of biomedical research for years, evolutionary biology has not been part of the conversation—until now. How Men Age is the first book to explore how natural selection has shaped male aging, how evolutionary theory can inform our understanding of male health and well-being, and how older men may have contributed to the evolution of some of the very traits that make us human. In this informative and entertaining book, renowned biological anthropologist Richard Bribiescas looks at all aspects of male aging through an evolutionary lens. He describes how the challenges males faced in their evolutionary past influenced how they age today, and shows how this unique evolutionary history helps explain common aspects of male aging such as prostate disease, loss of muscle mass, changes in testosterone levels, increases in fat, erectile dysfunction, baldness, and shorter life spans than women. Bribiescas reveals how many of the physical and behavioral changes that we negatively associate with male aging may have actually facilitated the emergence of positive traits that have helped make humans so successful as a species, including parenting, long life spans, and high fertility. Popular science at its most compelling, How Men Age provides new perspectives on the aging process in men and how we became human, and also explores future challenges for human evolution—and the important role older men might play in them.

Aging In Nonhuman Primates

Autore: Joseph Erwin
Editore: Karger Medical and Scientific Publishers
ISBN: 380557312X
Grandezza: 58,99 MB
Formato: PDF, ePub, Docs
Vista: 417
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As the number of elderly people in human populations increases, the study of normal aging, age-related disorders, and enhanced longevity is taking on new urgency. Fundamental research will provide means of preventing and effectively treating the most debilitating and distressing aspects of advanced age. Considerations of aging in nonhuman life forms do not aim at life extension, but at an increasing appreciation for the biological role of the aging process in populations, in addition to developing a more comprehensive understanding of the mechanisms of aging. The present volume focuses on primate aging because human characteristics that evolved during their evolution are homologous with those of other primates. Therefore, the research on nonhuman primates will decidedly also contribute to our understanding of the process of human aging. The topics of this volume include brain aging and neurodegenerative diseases, social behavior, cognition and aging, skeletal aging in natural and captive conditions, and consequences of caloric restriction for life and health extension. The great variety of contributions aim at providing a survey of the relevant work in progress and increasing the understanding of normal and pathological aging and life-span enhancement in a variety of nonhuman primate species.

Evolution And Morality

Autore: James E. Fleming
Editore: NYU Press
ISBN: 0814738435
Grandezza: 30,77 MB
Formato: PDF, Mobi
Vista: 8760
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Can theories of evolution explain the development of our capacity for moral judgment and the content of morality itself? If bad behavior punished by the criminal law is attributable to physical causes, rather than being intentional or voluntary as traditionally assumed, what are the implications for rethinking the criminal justice system? Is evolutionary theory and “nature talk,” at least as practiced to date, inherently conservative and resistant to progressive and feminist proposals for social changes to counter subordination and secure equality? In Evolution and Morality, a group of contributors from philosophy, law, political science, history, and genetics address many of the philosophical, legal, and political issues raised by such questions. This insightful interdisciplinary volume examines the possibilities of a naturalistic ethics, the implications of behavioral morality for reform of the criminal law, the prospects for a biopolitical science, and the relationship between nature, culture, and social engineering.

Physiological Basis Of Aging And Geriatrics Fourth Edition

Autore: Paola S. Timiras
Editore: CRC Press
ISBN: 9781420007091
Grandezza: 50,37 MB
Formato: PDF, ePub
Vista: 115
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Extensively revised and updated to reflect the current state of knowledge in the study of aging, this Fourth Edition offers a complete profile of the aging process at all levels, from molecules and cells to demography and evolution. Written by international experts in current basic and clinical aging research, this text includes aspects of individual, comparative, and differential aging, and discussions of theories and mechanisms of aging. This invaluable reference illustrates how bodily systems, organs, and functions are affected with aging, describes how genetic and environmental factors influence age-related changes, and addresses some of the clinical consequences of these changes for health and longevity. Well illustrated, with numerous tables and graphs, this book presents up-to-date information from internationally renowned experts in various bio-medical fields. New updated information includes: emphasis on emerging technologies and recent advances in biology and bioengineering that allow greater and longer independence of the elderly recent therapeutic developments in key diseases such as Alzheimer's, osteopenia, osteoporosis, high cholesterol, diabetes, gastritis, sexual impotence, and using transgenic animals as models of aging evaluation of the latest knowledge on the roles of oxidants and antioxidants, and correlates them with other aging-based theories expanded discussion of nutrition and physical exercise chapters on gene and stem cell interventions related to the aging process updated tables to reflect current trends, new research data, and up-to-date statistical information