Evolutionary Arguments On Aging Disease And Other Topicsn Aging

Autore: Giacinto Libertini
Editore: Azinet
ISBN: 0978870921
Grandezza: 63,99 MB
Formato: PDF, Kindle
Vista: 4694
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Every character of a living being has its function: the teeth are there to chew, the lungs to breathe, the eyes to see, etc. But what is the function of aging, if there even is one?If it is true that the living being is modelled by natural selection, what are the evolutionary needs that bring about limited longevity or variable longevity according to the species? Why does a mouse live less than two years, a tortoise many tens of years and Pinus Aristata not seem to age at all? Are these differences casual or is evolution somehow at the origin of it all, as A. Weismann hypothesized back in the last century?The results are beyond all expectations: it is possible to provide an explanation for the "why of senescence in evolutionary terms.Another important topic is the meaning of disease phenomenon in the context of evolutionary theory. Illness is a set of phenomena that is perfectly anticipated and rationally classifiable by evolutionary theory.This book, printed in Italian in 1983, broached these and other questions with a rigorous evolutionary approach, using mathematical models in its arguments for the graphic expression and the confirmation of the models.

Evolutionary Interpretations Of Aging Disease Phenomenon And Sex

Autore: Giacinto Libertini
Editore: Copernican editions
ISBN: 8890648600
Grandezza: 56,47 MB
Formato: PDF, Docs
Vista: 6844
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Cell Aging Molecular Mechanisms And Implications For Disease

Autore: Christian Behl
Editore: Springer Science & Business Media
ISBN: 3642451799
Grandezza: 51,54 MB
Formato: PDF, ePub
Vista: 2715
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Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Genetics And Evolution Of Aging

Autore: Michael R. Rose
Editore: Springer Science & Business Media
ISBN: 9401716714
Grandezza: 76,87 MB
Formato: PDF, Kindle
Vista: 8959
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Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. © 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

The Biology Of Human Longevity

Autore: Caleb E. Finch
Editore: Elsevier
ISBN: 9780080545943
Grandezza: 29,63 MB
Formato: PDF, ePub
Vista: 8647
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Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Evolution In Health And Disease

Autore: Stephen C. Stearns
Editore: Oxford University Press
ISBN: 0199207453
Grandezza: 55,81 MB
Formato: PDF, ePub
Vista: 2680
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A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.

Aging And Health A Systems Biology Perspective

Autore: A.I. Yashin
Editore: Karger Medical and Scientific Publishers
ISBN: 3318027308
Grandezza: 44,58 MB
Formato: PDF
Vista: 1108
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Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.

Successful Aging And Adaptation With Chronic Diseases

Autore: Betsy M. Sprouse, PhD
Editore: Springer Publishing Company
ISBN: 9780826119766
Grandezza: 44,53 MB
Formato: PDF, Mobi
Vista: 3533
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For many people growing old means facing one or more chronic diseases. Successful Aging and Adaptation with Chronic Diseases reviews, coalesces, and expands what we know about how older adults successfully experience the aging process and how they feel about and live with chronic illnesses. Questions considered include: How do older adults approach and deal with everyday-life when affected by multiple health problems? What kind of impact do they feel diseases have on their successful aging? How do existent models and theories of coping address these issues? Presenting research funded by the AARP Andrus Foundation, this book brings together contributions by originators in the field, including Robert Kahn and Ann Whall. This volume is sure to be a seminal reference point for future research.

Aging In Nonhuman Primates

Autore: Joseph Erwin
Editore: Karger Medical and Scientific Publishers
ISBN: 380557312X
Grandezza: 24,63 MB
Formato: PDF, ePub, Mobi
Vista: 2704
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As the number of elderly people in human populations increases, the study of normal aging, age-related disorders, and enhanced longevity is taking on new urgency. Fundamental research will provide means of preventing and effectively treating the most debilitating and distressing aspects of advanced age. Considerations of aging in nonhuman life forms do not aim at life extension, but at an increasing appreciation for the biological role of the aging process in populations, in addition to developing a more comprehensive understanding of the mechanisms of aging. The present volume focuses on primate aging because human characteristics that evolved during their evolution are homologous with those of other primates. Therefore, the research on nonhuman primates will decidedly also contribute to our understanding of the process of human aging. The topics of this volume include brain aging and neurodegenerative diseases, social behavior, cognition and aging, skeletal aging in natural and captive conditions, and consequences of caloric restriction for life and health extension. The great variety of contributions aim at providing a survey of the relevant work in progress and increasing the understanding of normal and pathological aging and life-span enhancement in a variety of nonhuman primate species.

Evolutionary Biology Of Aging

Autore: Michael R. Rose
Editore: Oxford University Press
ISBN: 9780198022725
Grandezza: 60,76 MB
Formato: PDF
Vista: 4256
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This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.