Evolutionary Arguments On Aging Disease And Other Topicsn Aging

Autore: Giacinto Libertini
Editore: Azinet
ISBN: 0978870921
Grandezza: 14,89 MB
Formato: PDF, Kindle
Vista: 9624
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Every character of a living being has its function: the teeth are there to chew, the lungs to breathe, the eyes to see, etc. But what is the function of aging, if there even is one?If it is true that the living being is modelled by natural selection, what are the evolutionary needs that bring about limited longevity or variable longevity according to the species? Why does a mouse live less than two years, a tortoise many tens of years and Pinus Aristata not seem to age at all? Are these differences casual or is evolution somehow at the origin of it all, as A. Weismann hypothesized back in the last century?The results are beyond all expectations: it is possible to provide an explanation for the "why of senescence in evolutionary terms.Another important topic is the meaning of disease phenomenon in the context of evolutionary theory. Illness is a set of phenomena that is perfectly anticipated and rationally classifiable by evolutionary theory.This book, printed in Italian in 1983, broached these and other questions with a rigorous evolutionary approach, using mathematical models in its arguments for the graphic expression and the confirmation of the models.

Evolutionary Interpretations Of Aging Disease Phenomenon And Sex

Autore: Giacinto Libertini
Editore: Copernican editions
ISBN: 8890648600
Grandezza: 12,61 MB
Formato: PDF, Kindle
Vista: 1001
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Evolution In Health And Disease

Autore: Stephen C. Stearns
Editore: Oxford University Press
ISBN: 0199207453
Grandezza: 20,46 MB
Formato: PDF, Mobi
Vista: 8835
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A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.

How Men Age

Autore: Richard G. Bribiescas
Editore: Princeton University Press
ISBN: 1400883261
Grandezza: 24,29 MB
Formato: PDF, Mobi
Vista: 5127
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While the health of aging men has been a focus of biomedical research for years, evolutionary biology has not been part of the conversation—until now. How Men Age is the first book to explore how natural selection has shaped male aging, how evolutionary theory can inform our understanding of male health and well-being, and how older men may have contributed to the evolution of some of the very traits that make us human. In this informative and entertaining book, renowned biological anthropologist Richard Bribiescas looks at all aspects of male aging through an evolutionary lens. He describes how the challenges males faced in their evolutionary past influenced how they age today, and shows how this unique evolutionary history helps explain common aspects of male aging such as prostate disease, loss of muscle mass, changes in testosterone levels, increases in fat, erectile dysfunction, baldness, and shorter life spans than women. Bribiescas reveals how many of the physical and behavioral changes that we negatively associate with male aging may have actually facilitated the emergence of positive traits that have helped make humans so successful as a species, including parenting, long life spans, and high fertility. Popular science at its most compelling, How Men Age provides new perspectives on the aging process in men and how we became human, and also explores future challenges for human evolution—and the important role older men might play in them.

Ageing Evidence

Autore:
Editore: The Stationery Office
ISBN: 9780104007280
Grandezza: 11,57 MB
Formato: PDF, ePub
Vista: 4231
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Cancer Autism And Their Epigenetic Roots

Autore: K. John Morrow, Jr.
Editore: McFarland
ISBN: 0786479205
Grandezza: 79,61 MB
Formato: PDF, Docs
Vista: 7779
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This book considers the branch of heredity known as "epigenetics" and its implications for a variety of diseases in humans and animals. After background information on the growth in understanding genetics and the mechanisms of the epigenetic control of gene expression, the book moves into its main focus: the gathering body of evidence connecting genetics to a range of significant illnesses, including cancer, autism, Alzheimer's disease, diabetes and others. Areas of uncertainty are stressed as well as the scientific debate concerning the role of environmental factors. The final chapters discuss the implications for society. Extensive notes provide additional details and personal anecdotes.

Aging By Design How New Thinking On Aging Will Change Your Life

Autore: Theodore C. Goldsmith
Editore: Azinet
ISBN: 097887093X
Grandezza: 38,21 MB
Formato: PDF
Vista: 4184
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Cell Aging Molecular Mechanisms And Implications For Disease

Autore: Christian Behl
Editore: Springer Science & Business Media
ISBN: 3642451799
Grandezza: 35,37 MB
Formato: PDF, Kindle
Vista: 4977
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Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

What Is Disease

Autore: James M. Humber
Editore: Springer Science & Business Media
ISBN: 1592594514
Grandezza: 40,86 MB
Formato: PDF, Mobi
Vista: 9063
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Renowned philosophers and medical ethicists debate and discuss the profoundly important concepts of disease and health. Christopher Boorse begins with an extensive reexamination of his seminal definition of disease as a value-free scientific concept. In responding to all those who criticized this view, which came to be called "naturalism" or "neutralism," Boorse clarifies and updates his landmark ideas on this crucial question. Other distinguished thinkers analyze, develop, and oftentimes defend competing, nonnaturalistic theories of disease. Their combined thoughts review and update an issue of central importance in bioethics today.

It S In Your Dna

Autore: Eugene Rosenberg
Editore: Academic Press
ISBN: 0128125683
Grandezza: 76,49 MB
Formato: PDF
Vista: 331
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It's in Your DNA: From Discovery to Structure, Function and Role in Evolution, Cancer and Aging describes, in a clear, approachable manner, the progression of the experiments that eventually led to our current understanding of DNA. This fascinating work tells the whole story from the discovery of DNA and its structure, how it replicates, codes for proteins, and our current ability to analyze and manipulate it in genetic engineering to begin to understand the central role of DNA in evolution, cancer, and aging. While telling the scientific story of DNA, this captivating treatise is further enhanced by brief sketches of the colorful lives and personalities of the key scientists and pioneers of DNA research. Major discoveries by Meischer, Darwin, and Mendel and their impacts are discussed, including the merging of the disciplines of genetics, evolutionary biology, and nucleic acid biochemistry, giving rise to molecular genetics. After tracing development of the gene concept, critical experiments are described and a new biological paradigm, the hologenome concept of evolution, is introduced and described. The final two chapters of the work focus on DNA as it relates to cancer and gerontology. This book provides readers with much-needed knowledge to help advance their understanding of the subject and stimulate further research. It will appeal to researchers, students, and others with diverse backgrounds within or beyond the life sciences, including those in biochemistry, genetics/molecular genetics, evolutionary biology, epidemiology, oncology, gerontology, cell biology, microbiology, and anyone interested in these mechanisms in life. Highlights the importance of DNA research to science and medicine Explains in a simple but scientifically correct manner the key experiments and concepts that led to the current knowledge of what DNA is, how it works, and the increasing impact it has on our lives Emphasizes the observations and reasoning behind each novel idea and the critical experiments that were performed to test them