Genes Environment And Alzheimer S Disease

Author: Orly Lazarov
Editor: Academic Press
ISBN: 0128028858
Size: 15,86 MB
Format: PDF, ePub
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Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Alzheimer S Disease A Century Of Scientific And Clinical Research

Author: G. Perry
Editor: IOS Press
ISBN: 1607501759
Size: 14,93 MB
Format: PDF
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This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

Gene Environment Interactions

Author: Lucio G. Costa
Editor: John Wiley & Sons
ISBN: 0471758035
Size: 15,13 MB
Format: PDF
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Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess genotypes, using such measurements inmolecular epidemiology studies, and the statistical issues involvedin their analysis. * Section 2 focuses on a number of key genetic polymorphismsrelevant for ecogenetics, including enzymes of phase I and phase IImetabolism, enzymes involved in DNA repair, as well as receptorsand ion channels. This highlights characteristics of selected,widely studied genotypic/phenotypic differences, and allowsdiscussion of how given genetic variations can influence responsesto exogenous chemicals. * Section 3 examines gene-environment interactions through adisease-based approach, addressing how genetic polymorphisms caninfluence susceptibility to various diseases. Chapters coverimportant disease conditions such as various types of cancer,neurodegenerative diseases, cardiovascular disease, chronicpulmonary diseases, infectious diseases, diabetes, andobesity. * The final section discusses the ethical, legal, and social issuesthat arise when investigating and evaluating genetic polymorphismsin human populations, as well as the impact of ecogenetics on riskassessment, regulatory policies, and medicine and publichealth. Packed with clear examples illustrating concepts, as well asnumerous tables and figures, Gene-Environment Interactions:Fundamentals of Ecogenetics is a unique resource for a wide rangeof physicians, students, and other specialists.

Alzheimer Disease New Insights For The Healthcare Professional 2013 Edition

Author:
Editor: ScholarlyEditions
ISBN: 1481663054
Size: 15,73 MB
Format: PDF, ePub
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Alzheimer Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Alzheimer Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alzheimer Disease: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Alzheimer S Disease

Author: Caroline McNeil
Editor: DIANE Publishing
ISBN: 9780788137938
Size: 12,60 MB
Format: PDF, ePub, Docs
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This report was written for people who are interested in research on Alzheimer's disease. Briefly covers the following areas of research: neurotransmitters, the proteins, the genes, environmental suspects, the calcium hypothesis, metabolism, cognitive markers, biological markers, caregiving, managing symptoms, potential biomedical treatments, and much more. Technical terms are defined in the glossary. Each chapter ends with a list of review articles and other materials that provide more detail on other studies mentioned in the text. Illustrated.

Life Span Human Development

Author: Carol K. Sigelman
Editor: Cengage Learning
ISBN: 1285454316
Size: 14,56 MB
Format: PDF, ePub, Docs
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Known for its clear, straightforward writing style, comprehensive coverage, strong and current research-based approach, and excellent visuals and tables, this life-span development text offers a topical organization at the chapter level and a consistent chronological presentation within each chapter. Each chapter focuses on a domain of development such as physical growth, cognition, or personality, and traces developmental trends and influences in that domain from infancy to old age. Within each chapter, you will find sections on four life stages: infancy, childhood, adolescence, and adulthood. This unique organization enables students to comprehend the processes of transformation that occur in key areas of human development. Another staple of the text is its emphasis on theories and how they apply to specific topics in each chapter. This new edition also asks students to engage more actively with the content, and includes a clear focus on the complex interactions of nature and nurture in development, more integrated coverage of culture and diversity, and an exciting new media package for both students and instructors. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Genetic Variants In Alzheimer S Disease

Author: Kevin Morgan
Editor: Springer Science & Business Media
ISBN: 1461473098
Size: 14,54 MB
Format: PDF
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Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

The Key Facts On Alzheimer S Disease

Author: Patrick W. Nee
Editor: The Internationalist
ISBN: 1484867777
Size: 13,79 MB
Format: PDF
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The Key Facts on Alzheimer’s Disease provides readers with essential, easy-to-read information on Alzheimer’s Disease. Compiled in a simplified manner, this guide helps patients navigate this painful and debilitating diseases without enduring the complicated nature of medical terminology. By making a patient-friendly manual to the causes, symptoms, treatment, and ongoing research of Alzheimer’s Disease, one can easily determine what they are facing and how to live their life to the fullest.

Inside The Brain

Author: Ronald Kotulak
Editor: Andrews McMeel Publishing
ISBN: 9780836232899
Size: 14,77 MB
Format: PDF, ePub, Mobi
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Explores how the brain learns, how it controls behavior, how it sustains damage and heals itself, and how scientists are searching for ways to keep it young and healthy.

Investigating Neurological Disease

Author: Albert Hofman
Editor: Cambridge University Press
ISBN: 9780521000093
Size: 16,47 MB
Format: PDF, ePub, Mobi
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This invaluable handbook for clinicians reviews the epidemiology, treatment and prognosis of all major diseases of the nervous system.