Handbook Of Statistics In Clinical Oncology

Author: John Crowley
Editor: CRC Press
ISBN: 142002776X
Size: 10,52 MB
Format: PDF, Kindle
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A compendium of cutting-edge statistical approaches to solving problems in clinical oncology, Handbook of Statistics in Clinical Oncology, Second Edition focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition a “1⁄4good reference book for statisticians who will be designing and analyzing cancer trials." The second edition includes over 1000 references, more than forty world-renowned contributors, and 300 equations, tables, and drawings. During the five years since publication of the first edition, there has been an explosion in the technological capabilities supporting genomic and proteomic research, which are is now firmly implanted in clinical oncology. Reflecting these developments, the second edition contains a new section devoted to analyses of high-throughput data and bioinformatics. Previous chapters of the first edition have been revised to reflect current state of the art in their respective domains. The intended audience is primarily statisticians working in cancer and more generally, in any discipline of medicine. But oncologists too will find the material accessible and will benefit from a rudimentary understanding of the fundamental concepts laid forth in each chapter. Completely revised while keeping the features that made the first edition a bestseller, this is the best single source for up-to-date statistical approaches to research in clinical medicine. More than just an update of the handbook that became the gold standard, this second edition brings you fully into the genomic era of medicine.

Handbook Of Statistics In Clinical Oncology Third Edition

Author: John Crowley
Editor: CRC Press
ISBN: 1439862001
Size: 11,46 MB
Format: PDF, Mobi
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Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Methodik Klinischer Studien

Author: Martin Schumacher
Editor: Springer-Verlag
ISBN: 3540369902
Size: 10,82 MB
Format: PDF, Kindle
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Praxisorientierte Einführung in die methodischen Grundlagen klinischer Studien in Forschung und Industrie. Prinzipien zur Planung und Durchführung sowie die wichtigsten statistischen Verfahren zur Auswertung sind verständlich dargestellt und erklärt: Methodik für Therapiestudien, spezielle Verfahren von Diagnose- und Prognosestudien. Anhand von Beispielen konkreter Studien - vorwiegend aus ihrem eigenen Arbeitsumfeld - illustrieren die Autoren anschaulich Prinzipien und Methoden, und zeigen exemplarisch in der Praxis auftretende Probleme. Plus: historische und neue Entwicklungen, internationale Qualitätsstandards, aktuelle Anforderungen.

The Cancer Handbook

Author: Malcolm Alison
Editor:
ISBN: 9780470018521
Size: 16,56 MB
Format: PDF, Kindle
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Oncology Clinical Trials

Author: Susan Halabi, PhD
Editor: Demos Medical Publishing
ISBN: 9781935281764
Size: 19,78 MB
Format: PDF, ePub, Docs
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Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial resources and challenges the validity of the ethical contract between investigators and the volunteers who willingly give their time and effort to benefit future patients. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives, Oncology Clinical Trials, provides a comprehensive guide for both early-career and senior oncology investigators into the successful design, conduct and analysis of an oncology clinical trial. Oncology Clinical Trials covers how to formulate a study question, selecting a study population, study design of Phase I, II, and III trials, toxicity monitoring, data analysis and reporting, use of genomics, cost-effectiveness analysis, systemic review and meta-analysis, and many other issues. Many examples of real-life flaws in clinical trials that have been reported in the literature are included throughout. The book discusses clinical trials from start to finish focusing on real-life examples in the development, design and analysis of clinical trials. Oncology Clinical Trials features: A systematic guide to all aspects of the design, conduct, analysis, and reporting of clinical trials in oncology Contributions from oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives Hot topics in oncology trials including multi-arm trials, meta-analysis and adaptive design, use of genomics, and cost-effectiveness analysis Real-life examples from reported clinical trials included throughout

Biostatistics In Clinical Trials

Author: Carol K. Redmond
Editor: John Wiley & Sons
ISBN: 9780471822110
Size: 18,59 MB
Format: PDF, ePub, Mobi
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The second volume in the Wiley reference series in Biostatistics. Featuring articles from the prestigious Encyclopedia of Biostatistics, many of which have been fully revised and updated to include recent developments, Biostatistics in Clinical Trials also includes up to 25% newly commissioned material reflecting the latest thinking in: Bayesian methods Benefit/risk assessment Cost-effectiveness Ethics Fraud With exceptional contributions from leading experts in academia, government and industry, Biostatistics in Clinical Trials has been designed to complement existing texts by providing extensive, up-to-date coverage and introducing the reader to the research literature. Offering comprehensive coverage of all aspects of clinical trials Biostatistics in Clinical Trials: Includes concise definitions and introductions to numerous concepts found in current literature Discusses the software and textbooks available Uses extensive cross-references helping to facilitate further research and enabling the reader to locate definitions and related concepts Biostatistics in Clinical Trials offers both academics and practitioners from various disciplines and settings, such as universities, the pharmaceutical industry and clinical research organisations, up-to-date information as well as references to assist professionals involved in the design and conduct of clinical trials.

Handbook Of Cardiac Electrophysiology Second Edition

Author: Andrea Natale
Editor: CRC Press
ISBN: 1482214946
Size: 10,91 MB
Format: PDF, Kindle
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This second edition of a bestseller provides a practical, user-friendly manual guiding the theory and practice of cardiac electrophysiolology. The handbook provides the specialist in training with a thorough grounding procedures, and clinical findings for clinicians. It provides a review of the main kinds of arrhythmia with illustrations of typical ECG findings supported where appropriate by correlative imaging. It also details the principal diagnostic and therapeutic procedures include implantation of pacemakers, resynchronization therapy, and ablation techniques.

Gynecologic Oncology Handbook

Author: Michelle Benoit, MD
Editor: Springer Publishing Company
ISBN: 1617052965
Size: 17,71 MB
Format: PDF, Docs
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Now in its second edition, Gynecologic Oncology Handbook: An Evidence-Based Clinical Guide has been thoroughly updated to include the latest advances in surgical techniques, chemotherapy protocols, AJCC 8th Edition staging criteria, and much more. This current edition contains illustrations that reinforce key concepts, algorithms for diagnostic techniques, and tables to guide you in optimal disease management. The handbook covers the spectrum of gynecologic oncology from seminal studies to guide the oncologist, to the essential workup for the Obstetrician/Gynecologist and related clinician. This handbook can be carried by the practitioner on the ward or in the clinic. It includes necessary details on gynecologic cancer screening and treatment regimens for preinvasive disease, to staging and management of all the gynecologic cancers such as cervical cancer, ovarian cancer, uterine cancer, vulvar cancer, vaginal cancer, and gestational trophoblastic disease. It highlights evidence-based best practices for managing these cancers, hereditary cancer syndromes, for surgical care, and for all adjuvant therapies including chemotherapy, radiation therapy, targeted therapies, and immunotherapies. Detailed sections on survivorship care, palliative care, as well as managing reproductive function and other comorbid medical conditions make this a ‘one-stop shop’ for navigating all clinical aspects and effects of gynecologic cancer. Featuring new and important clinical study references, medical comorbidity algorithms, directed gynecologic cancer workups and treatments, numerous tables and easy-to-reference illustrations, the Gynecologic Oncology Handbook, 2nd Edition is the ultimate quick reference for the clinical management of all gynecologic malignancies and related conditions. Key Features: Covers all fundamentals of gynecologic oncology including workup, staging, surgical management, chemotherapy and radiation therapy treatment, comorbidity diagnosis and management, and background study data Provides Gynecologic Oncology Referral Parameters, Performance Status Scales, Adverse Event Grading, RECIST evaluation criteria, chemotherapy protocols, statistics, and other useful formulas. Includes clinical study references, medical comorbidity algorithms, directed workups, and treatment guidelines

Journal Of The American Statistical Association

Author:
Editor:
ISBN:
Size: 15,89 MB
Format: PDF
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Textbook Of Clinical Trials

Author: David Machin
Editor: John Wiley & Sons
ISBN:
Size: 14,26 MB
Format: PDF
Read: 599
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Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a single comprehensive volume. Praise for the First Edition: "... very useful as an introduction to clinical research, or for those planning specific studies within therapeutic or disease areas." BRITISH JOURNAL OF SURGERY, Vol. 92, No. 2, February 2005 The book’s main concept is to describe the impact of clinical trials on the practice of medicine. It separates the information by therapeutic area because the impact of clinical trials, the problems encountered, and the numbers of trials in existence vary tremendously from specialty to specialty. The sections provide a background to the disease area and general clinical trial methodology before concentrating on particular problems experienced in that area. Specific examples are used throughout to address these issues. The Textbook of Clinical Trials, Second Edition: Highlights the various ways clinical trials have influenced the practice of medicine in many therapeutic areas Describes the challenges posed by those conducting clinical trials over a range of medical specialities and allied fields Additional therapeutic areas are included in this Second Edition to fill gaps in the First Edition as the number and complexity of trials increases in this rapidly developing area Newly covered or updated in the Second Edition: general surgery, plastic surgery, aesthetic surgery, palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal, thyroid and urological cancers, as well as a chapter on the Cochrane network An invaluable resource for pharmaceutical companies, the Textbook of Clinical Trials, Second Edition appeals to those working in contract research organizations, medical departments and in the area of public health and health science alike.