Introduction To Molecular Vaccinology

Author: Matthias Giese
Editor: Springer
ISBN: 331925832X
Size: 19,51 MB
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This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Bioinformatics For Vaccinology

Author: Darren R. Flower
Editor: John Wiley & Sons
ISBN: 0470699825
Size: 14,87 MB
Format: PDF, Kindle
Read: 277

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Bacterial Resistance To Antibiotics

Author: Boyan B. Bonev
Editor: John Wiley & Sons
ISBN: 1119558220
Size: 18,79 MB
Format: PDF
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AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.


Author: Alan D. T. Barrett
Editor: John Wiley & Sons
ISBN: 0470656166
Size: 16,45 MB
Format: PDF, Mobi
Read: 263

Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Innovation In Vaccinology

Author: Selene Baschieri
Editor: Springer Science & Business Media
ISBN: 9400745435
Size: 19,56 MB
Format: PDF, ePub, Mobi
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Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.


Author: H. Bazin
Editor: John Libbey Eurotext
ISBN: 274200775X
Size: 14,56 MB
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This English language edition is far more than a simple translation of the work "L'Histoire des vaccinations" published in 2008. The French edition has actually been totally revised and improved. In particular, it features a chapter dedicated entirely to yellow fever. A greater number of illustrations are included. This book will undoubtedly be of great interest to a section of the general public and to specialists. The history of vaccinations is a significant phase in the history of humanity. With the development of hygiene, vaccinations have certainly been the most notable progress of medicine. Nevertheless, this subject which has revolutionised human and animal medicine has long been explored poorly or not at all. This oversight has now been addressed through this fascinating work. All translated Pasteur texts are from the original manuscripts found in his laboratory notebooks. Finally, the moral problems inherent in the use of vaccines are addressed and at times, appear strangely similar to current situations. . .

Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines

Author: Darren R. Flower
Editor: Springer Science & Business Media
ISBN: 1461450705
Size: 20,38 MB
Format: PDF, Mobi
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This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Progress In Fish Vaccinology

Author: Paul J. Midtlyng
Editor: S Karger Ag
Size: 14,46 MB
Format: PDF, Docs
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This volume gives a comprehensive update on recent developments in fish vaccinology and the potential and current use of vaccines in modern fish farming. Among the topics presented in 25 overview articles and original contributions are: new findings on immune mechanisms in fish and crustaceans update on bacterial and viral vaccines for farmed fish overview of adjuvant technology and mechanisms causing adverse effects bath immunisation using ultrasound, and oral vaccination methods development of recombinant, live and DNA vaccines for fish critical assessment of regulatory standards and tests immunological control of reproduction The book will be an indispensable aid and source of up-to-date information for fish health professionals, managers in the aquaculture industry, and industrial researchers working in the field of fish immunology, vaccine development and disease control worldwide.

In Silico Immunology

Author: Darren D.R. Flower
Editor: Springer Science & Business Media
ISBN: 0387392416
Size: 20,92 MB
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This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.

Fish Vaccinology

Author: Roar Gudding
Editor: S. Karger AG (Switzerland)
ISBN: 9783805564823
Size: 18,86 MB
Format: PDF, Docs
Read: 528