Progress In Medicinal Chemistry

Author: F. D. King
Editor: Gulf Professional Publishing
ISBN: 9780444515728
Size: 14,64 MB
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Annotation The complex and multidisciplinary nature of modern drug discovery is well illustrated in the six chapters of this volume that describe exciting developments in both newly emerging and mature areas of medicinal chemistry. Chapter 1 provides a comprehensive review of therapeutic applications of ligands for peroxisome proliferator-activated receptor gamma PPAR?, a key regulator of glucose and lipid homeostasis. Progress over the last decade on ligands that bind to central nicotinic acetylcholine receptors is timely reviewed in Chapter 2, with the emphasis on the a4ß2 subtype. Chapter 3 reviews inhibitors of PARP-1, the founding member of the family, with the focus on their therapeutic potential in ischaemia related CNS injuries. Chapter 4 describes the structure-activity relationships of some semi-synthetic analogues including promising new compounds in development. Chapter 5 describes selective, first generation, non-peptidic neuropeptide Y1 and Y2 antagonists and their actions and evaluates their potential therapeutic application in cardiovascular disorders, with the emphasis on NPY1 antagonists. Chapter 6 is an extensive review of the considerable progress that has been achieved in developing Cathepsin K inhibitors and evaluates their potential for treating arthritis and atherosclerosis.

Progress In Medicinal Chemistry

Author:
Editor: Elsevier
ISBN: 9780080862637
Size: 11,87 MB
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Progress in Medicinal Chemistry

Progress In Medicinal Chemistry

Author: G. Lawton
Editor: Newnes
ISBN: 0444533001
Size: 13,69 MB
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This volume provides reviews of six topics demonstrating the breadth of the field and recent successes in medicinal chemistry. Each of the first five chapters takes an important biochemical target as its theme and provides an insight into current progress in drug design. The last chapter focuses on the vital subject of pharmacokinetics and the great strides that have been made in this discipline during the past decade. All chapters provide an insight into the skills required of the modern medicinal chemist, in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. *Presents the latest research in the field of drug discovery *Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

Progress In Medicinal Chemistry

Author: G. P. Ellis
Editor: Elsevier Science & Technology
ISBN: 9780444809650
Size: 13,68 MB
Format: PDF, ePub, Docs
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Progress In Medicinal Chemistry

Author: G. P. Ellis
Editor:
ISBN: 9780720406450
Size: 20,65 MB
Format: PDF, ePub
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Progress In Medicinal Chemistry

Author: Frank D. King
Editor:
ISBN: 0444517375
Size: 16,35 MB
Format: PDF, ePub
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Progress In Medicinal Chemistry 21

Author: Gwynn Pennant Ellis
Editor:
ISBN: 9780720474008
Size: 13,90 MB
Format: PDF, Docs
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2015 Medicinal Chemistry Reviews

Author:
Editor:
ISBN: 9780996293204
Size: 16,82 MB
Format: PDF, Mobi
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This is the annual review of progress in medicinal chemistry produced by the Medicinal Chemistry Division of the American Chemical Society

Medicinal Chemistry Research Progress

Author: Giulia P. Colombo
Editor: Nova Biomedical
ISBN: 9781604565805
Size: 13,42 MB
Format: PDF, ePub
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Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacology involved with designing, synthesising and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, pharmacognosy, molecular biology, statistics, and physical chemistry. This book presents leading research from around the world in this frontal field.

Medicinal Chemistry Of Bioactive Natural Products

Author: Xiao-Tian Liang
Editor: John Wiley & Sons
ISBN: 0471739332
Size: 16,77 MB
Format: PDF, ePub, Mobi
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Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics