Progress In Medicinal Chemistry

Author: G. Lawton
Editor: Elsevier
ISBN: 0123964938
Size: 18,73 MB
Format: PDF, ePub, Docs
Read: 573
Download

Annual Review of Eclectic Developments in Medicinal Chemistry *Presents the latest research in the field of drug discovery *Publishes yearly bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

Progress In Medicinal Chemistry

Author: F. D. King
Editor: Gulf Professional Publishing
ISBN: 9780444515728
Size: 13,53 MB
Format: PDF, ePub, Docs
Read: 728
Download

Annotation The complex and multidisciplinary nature of modern drug discovery is well illustrated in the six chapters of this volume that describe exciting developments in both newly emerging and mature areas of medicinal chemistry. Chapter 1 provides a comprehensive review of therapeutic applications of ligands for peroxisome proliferator-activated receptor gamma PPAR?, a key regulator of glucose and lipid homeostasis. Progress over the last decade on ligands that bind to central nicotinic acetylcholine receptors is timely reviewed in Chapter 2, with the emphasis on the a4ß2 subtype. Chapter 3 reviews inhibitors of PARP-1, the founding member of the family, with the focus on their therapeutic potential in ischaemia related CNS injuries. Chapter 4 describes the structure-activity relationships of some semi-synthetic analogues including promising new compounds in development. Chapter 5 describes selective, first generation, non-peptidic neuropeptide Y1 and Y2 antagonists and their actions and evaluates their potential therapeutic application in cardiovascular disorders, with the emphasis on NPY1 antagonists. Chapter 6 is an extensive review of the considerable progress that has been achieved in developing Cathepsin K inhibitors and evaluates their potential for treating arthritis and atherosclerosis.

Progress In Medicinal Chemistry

Author: Gwynn Pennant Ellis
Editor:
ISBN: 9780720474008
Size: 19,20 MB
Format: PDF, Docs
Read: 535
Download


Progress In Medicinal Chemistry

Author:
Editor: Elsevier
ISBN: 9780080862828
Size: 11,57 MB
Format: PDF, ePub
Read: 797
Download

There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.

Progress In Medicinal Chemistry

Author: Frank D. King
Editor:
ISBN: 0444517375
Size: 11,38 MB
Format: PDF, ePub, Docs
Read: 615
Download


Progress In Medicinal Chemistry

Author: David R. Witty
Editor: Progress in Medicinal Chemistr
ISBN: 9780444639394
Size: 10,86 MB
Format: PDF
Read: 863
Download

Progress in Medicinal Chemistry, Volume 56 provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development. Specific chapters cover timely topics, such as the development of LRRK2 inhibitors for the treatment of Parkinson's, and recent discoveries and developments in TRPA1 modulators. Users will find a comprehensive resource on the topic of medicinal chemistry that also discusses avenues for the acceleration of drug discovery programs. Extended, timely reviews of topics in medicinal chemistry Contains targets and technologies relevant to the discovery of tomorrow's drugs Presents analyses of successful drug discovery programs

Annual Reports In Medicinal Chemistry

Author:
Editor: Academic Press
ISBN: 0128003723
Size: 12,74 MB
Format: PDF, Mobi
Read: 907
Download

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Reviews on hot topics of interest in small molecule drug discovery heavily pursued by industrial research organizations Provides preclinical information in the context of chemical structures Knowledgeable section editors who evaluate invited reviews for scientific rigor

The Practice Of Medicinal Chemistry

Author: Camille Georges Wermuth
Editor: Elsevier
ISBN: 012417213X
Size: 16,21 MB
Format: PDF, Docs
Read: 393
Download

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Medicinal Chemistry Of Bioactive Natural Products

Author: Xiao-Tian Liang
Editor: John Wiley & Sons
ISBN: 0471739332
Size: 11,70 MB
Format: PDF, Kindle
Read: 933
Download

Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and its analogs * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer's disease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIV agents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics