Structural Biology Using Electrons And X Rays

Author: Michael F Moody
Editor: Academic Press
ISBN: 9780080919454
Size: 17,54 MB
Format: PDF, ePub
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Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen’s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. Emphasis on common principles underlying all diffraction-based methods Thorough grounding in theory requires understanding of only simple algebra Visual representations and explanations of challenging content Mathematical detail offered in short-course form to parallel the text

Introduction To Molecular Biology Genomics And Proteomics For Biomedical Engineers

Author: Robert B. Northrop
Editor: CRC Press
ISBN: 1420061216
Size: 18,90 MB
Format: PDF, Mobi
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Illustrates the Complex Biochemical Relations that Permit Life to Exist It can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to their chosen profession. Introduction to Molecular Biology, Genomics, and Proteomics for Biomedical Engineers hones in on the specialized organic molecules in living organisms and how they interact and react. The book’s sound approach to this intricately complex field makes it an exceptional resource for further exploration into the biochemistry, molecular biology, and genomics fields. It is also beneficial for electrical, chemical, and civil engineers as well as biophysicists with an interest in modeling living systems. This seminal reference includes many helpful tools for self study, including— 143 illustrations, 32 in color, to bolster understanding of complex biochemical relations 20 tables for quick access to precise data 100 key equations Challenging self-study problems within each chapter Conveys Human Progress in the Manipulation of Genomes at the Molecular Level In response to growing global interest in biotechnology, this valuable text sheds light on the evolutionary theories and future trends in genetic medicine and stem cell research. It provides a broader knowledge base on life-permitting complexities, illustrates how to model them quantitatively, and demonstrates how to manipulate them in genomic-based medicine and genetic engineering. Consequently, this book allows for a greater appreciation among of the incredible complexity of the biochemical systems required to sustain life in its many forms. A solutions manual is available for instructors wishing to convert this reference to classroom use.

Electron Crystallography

Author: D. Dorset
Editor: Springer Science & Business Media
ISBN: 9401589712
Size: 18,38 MB
Format: PDF, ePub
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The re-emergent field of quantitative electron crystallography is described by some of its most eminent practitioners. They describe the theoretical framework for electron scattering, specimen preparation, experimental techniques for optimum data collection, the methodology of structure analysis and refinement, and a range of applications to inorganic materials (including minerals), linear polymers, small organic molecules (including those used in nonlinear optical devices), incommensurately modulated structures (including superconductors), alloys, and integral membrane proteins. The connection between electron crystallography and X-ray crystallography is clearly defined, especially in the utilisation of the latest methods for direct determination of crystallographic phases, as well as the unique role of image analysis of high-resolution electron micrographs for phase determination. Even the aspect of multiple beam dynamic diffraction (once dreaded because it was thought to preclude ab initio analysis) is considered as a beneficial aid for symmetry determination as well as the elucidation of crystallographic phases, and as a criterion for monitoring the progress of structure refinement. Whereas other texts have hitherto preferentially dealt with the analysis of electron diffraction and image data from thin organic materials, this work discusses - with considerable optimism - the prospects of looking at `harder' materials, composed of heavier atoms. Audience: Could be used with profit as a graduate-level course on electron crystallography. Researchers in the area will find a statement of current progress in the field.

Fundamentals Of Biochemical Pharmacology

Author: Z. M. Bacq
Editor: Elsevier
ISBN: 1483181626
Size: 18,80 MB
Format: PDF
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Fundamentals of Biochemical Pharmacology explains the molecular aspects of drugs and the changes in bio-chemical systems. The cellular movements that result from such changes are also evaluated. Biochemical lesion is extensively defined in the book. A discussion on electromagnetic radiation is also provided. A chapter of the book is devoted to the principles of electronic and nuclear magnetic resonance. The principles and applications of mass spectrometry and combined gas chromatography are then discussed. The scientific advances made with the use of immunological methods are the focus of a section of the book. Another section provides an introduction to the kinetic properties of reactions made by enzymes. The process called homogenization is clearly explained along with a discussion on the use of electron microscopy. Autoradiography shows the distribution of compounds at the subcellular level. The theoretical background of molecular spectroscopy is presented completely. The book is intended for chemists, biochemists, physicists, micro-biologists, zoologists, and botanists .

An Introduction To Microscopy By Means Of Light Electrons X Rays Or Ultrasound

Author: Eugene Rochow
Editor: Springer Science & Business Media
ISBN: 1468424548
Size: 12,36 MB
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Many people look upon a microscope as a mere instrument(l); to them microscopy is instrumentation. Other people consider a microscope to be simply an aid to the eye; to them microscopy is primarily an expan sion of macroscopy. In actuality, microscopy is both objective and sub jective; it is seeing through an instrument by means of the eye, and more importantly, the brain. The function of the brain is to interpret the eye's image in terms of the object's structure. Thought and experience are required to distinguish structure from artifact. It is said that Galileo (1564-1642) had his associates first look through his telescope microscope at very familiar objects to convince them that the image was a true representation of the object. Then he would have them proceed to hitherto unknown worlds too far or too small to be seen with the un aided eye. Since Galileo's time, light microscopes have been improved so much that performance is now very close to theoretical limits. Electron microscopes have been developed in the last four decades to exhibit thousands of times the resolving power of the light microscope. Through the news media everyone is made aware of the marvelous microscopical accomplishments in imagery. However, little or no hint is given as to what parts of the image are derived from the specimen itself and what parts are from the instrumentation, to say nothing of the changes made during preparation of the specimen.

Synchrotron Radiation Applications

Author: Zhang Xinyi
Editor: World Scientific
ISBN: 9813227680
Size: 19,46 MB
Format: PDF, Docs
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This is a research-level review volume. It presents both the fundamentals and the advanced research results, covering most part of important aspects of synchrotron radiation applications. Among the broad subjects of synchrotron radiation applications, as the main content of this book we have applications in VUV, soft X-rays, hard X-rays and XFEL (X-ray free electron laser) and important applications by various synchrotron-based techniques and methods, such as ARPES (angle-resolved photoemission spectroscopy), VUV photo-ionization spectroscopy, X-ray absorption/emission spectroscopy and X-ray absorption fine structure, X-ray diffraction, small angle X-ray scattering, X-ray excited optical luminescence, imaging and high pressure techniques. Contents: Angle Resolved Photoemission Spectroscopy Study Utilizing the Synchrotron Radiation (Yan Zhang, Dawei Shen, and Donglai Feng) Synchrotron-Based VUV Photoionization Mass Spectrometry in Combustion Chemistry Research (Nils Hansen, Bin Yang, and Tina Kasper) Developments on Synchrotron X-Ray Diffraction (Qiyun Xie and Xiaoshan Wu) Structural Biology and Synchrotron Radiation (Zihe Rao and Zhiyong Lou) Fluorescence Detected XAS — Unconventional Applications (Hiroyuki Oyanagi) The Application of X-Ray Absorption Fine Structure Spectroscopy in Functional Materials (Zhihu Sun, Xinyi Zhang, and Shiqiang Wei) Small Angle X-Ray Scattering and Its Applications (Zhonghua Wu and Xueqing Xing) Crystal-Based X-Ray Medical Imaging Using Synchrotron Radiation and Its Future Prospect (Masami Ando, Naoki Sunaguchi, Yongjin Sung, Daisuke Shimao, Jong-Ki Kim, Gang Li, Yoshifumi Suzuki, Tetsuya Yuasa, Kensaku Mori, Shu Ichihara and Rajiv Gupta) X-Ray Imaging and Its Applications (Tiqiao Xiao and Honglan Xie) Synchrotron Radiation Applications in Medicine (Yifeng Peng, Liangqi Wang, Chenglin Liu, Alberto Bravin, Gang Li, Shaoliang Chen, Yongting Wang, Guo-Yuan Yang and Xinyi Zhang) Synchrotron Radiation Applications on High-Pressure Research (Bo Zou, Kai Wang, Shourui Li and Guangtian Zou) X-Ray Excited Optical Luminescence and Its Applications (Lijia Liu and Xuhui Sun) A Compact X-Ray Free-Electron Laser: SACLA (Hitoshi Tanaka, Takashi Tanaka, Kei Sawada, Makina Yabashi, and Tetsuya Ishikawa) Femtosecond Imaging of Single Particles and Molecules Using X-Ray Free-Electron Lasers (Andrew V Martin and N Duane Loh) Readership: Graduate students and professionals working on synchrotron radiation. Keywords: Angle Resolved Photoemission Spectroscopy (ARPES);Coherent Diffractive Imaging (CDI);Combustion;Detactor Development;Free-Electron Laser;High Pressure;Medical Imaging;Nanomaterials;Photoemission Spectroscopy;Protein Crystallography;Serial Femtosecond Crystallography (SFX);Single Particles and Molecules;Small Angle X-Ray Scattering;Strongly Correlated Materials;Surface X-Ray Diffraction;Synchrotron Radiation Applications;Table Top X-Ray Source;VUV Photoionization Mass Spectrometry;X-Ray Absorption Fine Structure (XAFS);X-Ray Absorption Spectroscopy (XAS);X-Ray Excited Optical Luminescence (XEOL);X-Ray Fluorescence (XRF)Review: Key Features: The book contains the latest synchrotron-based techniques and research results All contributors are specialists or leading scientists in their fields The book includes new techniques and methods that will potentially get wider applications in various disciplines

Molecular Biology Of The Cell

Author: Bruce Alberts
Editor: Garland Science
ISBN: 1317563743
Size: 16,77 MB
Format: PDF
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Membrane Protein Crystallization

Author:
Editor: Academic Press
ISBN: 9780080961590
Size: 17,13 MB
Format: PDF, Kindle
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This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization. This publication also includes tools to enchance membrane protein crystallization, technique advancements, and crystallization strategies used for photosystem I and its complexes, establishing Membrane Protein Crystallization as a needed, practical reference for researchers.

Scanning Electron Microscopy For The Life Sciences

Author: Heide Schatten
Editor: Cambridge University Press
ISBN: 0521195993
Size: 12,56 MB
Format: PDF, Mobi
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A guide to modern scanning electron microscopy instrumentation, methodology and techniques, highlighting novel applications to cell and molecular biology.

Introduction To The Physics And Chemistry Of Materials

Author: Robert J. Naumann
Editor: CRC Press
ISBN: 1420061348
Size: 15,17 MB
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Discusses the Structure and Properties of Materials and How These Materials Are Used in Diverse Applications Building on undergraduate students’ backgrounds in mathematics, science, and engineering, Introduction to the Physics and Chemistry of Materials provides the foundation needed for more advanced work in materials science. Ideal for a two-semester course, the text focuses on chemical bonding, crystal structure, mechanical properties, phase transformations, and materials processing for the first semester. The material for the second semester covers thermal, electronic, photonic, optical, and magnetic properties of materials. Requiring no prior experience in modern physics and quantum mechanics, the book introduces quantum concepts and wave mechanics through a simple derivation of the Schrödinger equation, the electron-in-a-box problem, and the wave functions of the hydrogen atom. The author also presents a historical perspective on the development of the materials science field. He discusses the Bose–Einstein, Maxwell–Boltzmann, Planck, and Fermi–Dirac distribution functions, before moving on to the various properties and applications of materials. With detailed derivations of important equations, this applications-oriented text examines the structure and properties of materials, such as heavy metal glasses and superconductors. It also explores recent developments in organics electronics, polymer light-emitting diodes, superconductivity, and more.