Structural Biology Using Electrons And X Rays

Author: Michael F Moody
Editor: Academic Press
ISBN: 9780080919454
Size: 11,83 MB
Format: PDF, Kindle
Read: 133

Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen’s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. Emphasis on common principles underlying all diffraction-based methods Thorough grounding in theory requires understanding of only simple algebra Visual representations and explanations of challenging content Mathematical detail offered in short-course form to parallel the text

X Ray Free Electron Lasers

Author: Sébastien Boutet
Editor: Springer
ISBN: 3030005518
Size: 20,78 MB
Format: PDF, ePub
Read: 454

The timely volume describes recent discoveries and method developments that have revolutionized Structural Biology with the advent of X-ray Free Electron Lasers. It provides, for the first time, a comprehensive examination of this cutting-edge technology. It discusses of-the-moment topics such as growth and detection of nanocrystals, Sample Delivery Techniques for serial femtosecond crystallography, data collection methods at XFELs, and more. This book aims to provide the readers with an overview of the new methods that have been recently developed as well as a prospective on new methods under development. It highlights the most important and novel Structural Discoveries made recently with XFELS, contextualized with a big-picture discussion of future developments.

Introduction To Molecular Biology Genomics And Proteomics For Biomedical Engineers

Author: Robert B. Northrop
Editor: CRC Press
ISBN: 1420061216
Size: 17,41 MB
Format: PDF, Mobi
Read: 591

Illustrates the Complex Biochemical Relations that Permit Life to Exist It can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to their chosen profession. Introduction to Molecular Biology, Genomics, and Proteomics for Biomedical Engineers hones in on the specialized organic molecules in living organisms and how they interact and react. The book’s sound approach to this intricately complex field makes it an exceptional resource for further exploration into the biochemistry, molecular biology, and genomics fields. It is also beneficial for electrical, chemical, and civil engineers as well as biophysicists with an interest in modeling living systems. This seminal reference includes many helpful tools for self study, including— 143 illustrations, 32 in color, to bolster understanding of complex biochemical relations 20 tables for quick access to precise data 100 key equations Challenging self-study problems within each chapter Conveys Human Progress in the Manipulation of Genomes at the Molecular Level In response to growing global interest in biotechnology, this valuable text sheds light on the evolutionary theories and future trends in genetic medicine and stem cell research. It provides a broader knowledge base on life-permitting complexities, illustrates how to model them quantitatively, and demonstrates how to manipulate them in genomic-based medicine and genetic engineering. Consequently, this book allows for a greater appreciation among of the incredible complexity of the biochemical systems required to sustain life in its many forms. A solutions manual is available for instructors wishing to convert this reference to classroom use.

Introduction To Electron Microscopy For Biologists

Editor: Academic Press
ISBN: 008088816X
Size: 16,70 MB
Format: PDF, Kindle
Read: 813

This volume demonstrates how cellular and associated electron microscopy contributes to knowledge about biological structural information, primarily at the nanometer level. It presents how EM approaches complement both conventional structural biology (at the high end, angstrom level of resolution) and digital light microscopy (at the low end, 100-200 nanometers). *Basic techniques in transmission and scanning electron microscopy *Detailed chapters on how to use electron microscopy when dealing with specific cellular structures, such as the nucleus, cell membrane, and cytoskeleton *Discussion on electron microscopy of viruses and virus-cell interactions

Biophysical Tools For Biologists

Author: John J. Correia
Editor: Academic Press
ISBN: 9780080554945
Size: 18,52 MB
Format: PDF, ePub, Mobi
Read: 933

Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. Describes techniques in the context of important biological problems Delineates critical steps and potential pitfalls for each method Includes full-color plates to illustrate techniques

Visualizing The Invisible

Author: Peter Moore
Editor: OUP USA
ISBN: 0199767092
Size: 11,96 MB
Format: PDF, ePub
Read: 906

Imaging of Biological Materials presents the four most important approaches to the imaging of biological structures: crystallography, non-crystallographic diffraction, optical microscopy, and electron microscopy.

Advances In Lipid Research

Author: Rodolfo Paoletti
Editor: Elsevier
ISBN: 1483224406
Size: 14,91 MB
Format: PDF, Mobi
Read: 785

Advances in Lipid Research, Volume 1 provides information pertinent to the structure and behavior of lipids through sulfolipids. This book presents the advances on fat absorption and transport. Organized into 10 chapters, this volume begins with an overview of the methods for the analysis of glycerine mixtures that require the determination of the fatty acid composition of the whole mixture and of its component fraction. This text then examines lipids as molecules of biological interest having little or no solubility in water. Other chapters cover the advances in cholesterol metabolism, Vitamin E as it affects lipid metabolism, and a discussion on atherosclerosis. This book discusses as well all areas of lipid research ranging from physical chemistry to physiology and pathology. The final chapter deals with sulfolipid, which appears to be concentrated in the lamellar membranes of the chloroplasts of plants. This book is a valuable resource for physical chemists, biologists, and pathologists.

Structural Bioinformatics

Author: Jenny Gu
Editor: John Wiley & Sons
ISBN: 0470181052
Size: 16,45 MB
Format: PDF, ePub
Read: 991

The second edition of this successful text expands on the depth and scope of the topic by bringing together many of the world's experts to provide a view of the current state of the field suitable for advanced undergraduate students, graduate students and beyond. The book begins with a description of the principles of protein, DNA and RNA structure, the methods used to collect the data, and how the data are represented, visualized and stored. With these prerequisites the comparative analysis of structure reveals classification schemes and how they are used in studies ranging from evolution to structure prediction. The physical properties of structure are explored to understand, for example, how macromolecules move and interact with each other and with ligands, offering insights into how drug discovery is undertaken and how structure can provide the details needed to understand complex molecular interactions important in fields such as immunology and systems biology. Finally, structural genomics reveals insight into the future role of structural bioinformatics where features, including function, are systematically assigned and the structural basis of complete organisms begin to emerge.

Frontiers Of Optical Spectroscopy

Author: Baldassare Di Bartolo
Editor: Springer Science & Business Media
ISBN: 9781402027499
Size: 16,89 MB
Format: PDF, ePub
Read: 230

Advanced spectroscopic techniques allow the probing of very small systems and very fast phenomena, conditions that can be considered "extreme" at the present status of our experimentation and knowledge. Quantum dots, nanocrystals and single molecules are examples of the former and events on the femtosecond scale examples of the latter. The purpose of this book is to examine the realm of phenomena of such extreme type and the techniques that permit their investigations. Each author has developed a coherent section of the program starting at a somewhat fundamental level and ultimately reaching the frontier of knowledge in the field in a systematic and didactic fashion. The formal lectures are complemented by additional seminars.

Recent Developments In Biomolecular Nmr

Author: Marius Clore
Editor: Royal Society of Chemistry
ISBN: 1849731209
Size: 17,71 MB
Format: PDF
Read: 676

Edited by leading biological NMR spectroscopists, this book will cover the new developments that have occurred in biomolecular NMR over the last few years.