The Chemical Biology Of Nucleic Acids

Author: Günter Mayer
Editor: John Wiley & Sons
ISBN: 1119957265
Size: 16,58 MB
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With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Chemical Biology Of Nucleic Acids

Author: Volker A. Erdmann
Editor: Springer Science & Business
ISBN: 3642544525
Size: 16,60 MB
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This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Nucleic Acids In Chemistry And Biology

Author: G Michael Blackburn
Editor: Royal Society of Chemistry
ISBN: 1782625771
Size: 17,51 MB
Format: PDF
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The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Medicinal Chemistry Of Nucleic Acids

Author: Li-He Zhang
Editor: John Wiley & Sons
ISBN: 9781118092811
Size: 13,57 MB
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Complete, up-to-date coverage of the broad area of nucleic acidchemistry and biology Assembling contributions from a collection of authors withexpertise in all areas of nucleic acids, medicinal chemistry, andtherapeutic applications, Medicinal Chemistry of NucleicAcids presents a thorough overview of nucleic acidchemistry—a rapidly evolving and highly challengingdiscipline directly responsible for the development of antiviraland antitumor drugs. This reliable resource delves into a multitudeof subject areas involving the study of nucleic acids—such asthe new advances in genome sequencing, and the processes forcreating RNA interference (RNAi) based drugs—to assistpharmaceutical researchers in removing roadblocks that hinder theirability to predict drug efficacy. Offering the latest cutting-edgescience in this growing field, Medicinal Chemistry of Nucleic Acidsincludes: In-depth coverage of the development and application of modifiednucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acidchemistry and biology Essential information on the use of nucleic acid drugs to treatdiseases like cancer A thorough exploration of siRNA for RNAi and the regulation ofmicroRNA, non-coding RNA (ncRNA), a newly developing and excitingresearch area Thorough in its approach and promising in its message,Medicinal Chemistry of Nucleic Acids probes the new domainsof pharmaceutical research—and exposes readers to a wealth ofnew drug discovery opportunities emerging in the dynamic field ofnucleic acid chemistry.

Chemical Biology

Author: H Gobind Khorana
Editor: World Scientific
ISBN: 9814496650
Size: 18,80 MB
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The first two chapters of this invaluable book trace the developments of the chemistry and macromolecular structures, respectively, of proteins and nuclei acids. Similarly, the introductions to the succeeding chapters review, step by step, the historical landmarks in the topics covered. These include discoveries of biological phosphate esters, nucleotides and nucleotide coenzymes (important in intermediary metabolism), the nature of the genetic material and biological synthesis of proteins, formulation of the problem of the genetic code, and perspectives on bioenergetics. The selected papers illustrate the developments of the chemical synthesis of nucleotides and nucleotide coenzymes of ribo- and deoxy-ribo-polynucleotides (RNA, DNA), of the total synthesis of genes in the laboratory, and principles for gene amplification (PCR). Another major section covers studies of enzymes that degrade nucleic acids, the structure of transfer RNA and its role in protein synthesis, and the author's work on the elucidation of the genetic code. Finally, there are descriptions of the studies on biological membranes and the membrane protein bacteriorhodopsin, a biological proton pump. These studies elucidated the mechanism of proton translocation, which is central to bioenergetics. Contents:Development of the Chemistry and Macromolecular Structures of ProteinsDevelopment of the Chemistry and Macromolecular Structures of Nucleic AcidsCarbodiimides as Synthetic ReagentsPhosphoric Acid Esters in Intermediary Metalbolism: Development of Methods for Their SynthesisChemical Synthesis of PolynucleotidesEnzymes That Degrade Nuclei AcidsThe Genetic Code: (A) Specificity in Protein Synthesis, The Transfer Ribonucleic AcidsThe Genetic Code: (B) Basic Features and Codon AssignmentsThe Total Synthesis of GenesGene Amplification (PCR)Bionergetics: Bacteriorhodopsin, a Light-Driven Proton Pump Readership: Researchers and students in organic chemistry, biochemistry, biophysics, molecular genetics and biotechnology. Keywords:Protein Chemistry;Nucleic Acids Chemistry;Carbodiimides;Organic Synthesis Reagents;ATP and High Energy Phosphates;Nucleic Acid Synthesis;Protein Biosynthesis;Genetic Code;Synthesis of Functional Genes;Development of PCR;Bioenergetics;BacteriorhodopsinReviews: “Khorana has been a leading scientist during a crucial period in the development of molecular biology and he intimately knew the people who influenced the field. He brings to this book the view of a chemist and he emphasizes the potential of organic chemistry in biology. This is a very important book for young scientists in the fields of molecular biology, genetics and medical science.” Amos Panet Professor of Cancer Research The Hebrew University, Jerusalem, Israel “Khorana is unique in his mastery of molecular biology, enzymology and organic chemistry. Only in this beautifully organized and illustrated volume can one find such a lively synthesis of these disciplines from the first synthesis of a gene to the mechanism in bioenergetics.” Arthur Kornberg Emeritus Professor of Biochemistry Stanford University School of Medicine “These pages present the beginnings of chemical gene synthesis, as described by its principal architect and builder, and accompanied by his perspectives on this exciting formative period in molecular biology.” Paul Zamecnik MD, Senior Scientist, Massachusetts General Hospital Emeritus Professor of Oncologic Medicine, Harvard Medical School Director Emeritus Huntington Laboratories, Harvard University “Through original research papers and historical overviews, this book demonstrates how studies on the basic chemistry of nucleic acids and their components, from as early as the 1950s, have been fundamental to solving the genetic code and the chemical synthesis of genes. As the book progresses to more recent work on bacteriorhodopsin and signal transduction one marvels how the author's motivation and detailed knowledge of phosphate chemistry has been instrumental in the progress of science.” Susumu Nishimura Ex-Director Biology Division of National Cancer Research Institute, Tokyo President Emeritus, Banyu Tsukuba Research Institute, Tsukuba, Japan “Khorana, a pioneer of chemical biology, shares in this beautifully presented book his spectacular contributions to the foundations of this rapidly expanding field.” Professor Dieter Soll Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA

Chemistry And Biology Of Artificial Nucleic Acids

Author: Martin Egli
Editor: Wiley-VCH
ISBN: 9783906390673
Size: 17,36 MB
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This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. Covering a tremendous amount of literature on the chemistry, biology, and structure of artificial nucleic acids, it will constitute an invaluable source of information for the specialist and for young researchers interested in starting a career in this fascinating field of research alike. This book combines the contributions of many of the major players in this research field, and covers the synthesis of sugar-, base- and backbone-modified nucleic acids, their structural characteristics studied by X-ray crystallography, and NMR in solution as well as their chemical and biological properties.

New Frontiers In Chemical Biology

Author: Mark E. Bunnage
Editor: Royal Society of Chemistry
ISBN: 184973125X
Size: 14,89 MB
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This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.

Modified Nucleic Acids In Biology And Medicine

Author: Stefan Jurga
Editor: Springer
ISBN: 3319341758
Size: 14,54 MB
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This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

Quadruplex Nucleic Acids

Author: Stephen Neidle
Editor: Royal Society of Chemistry
ISBN: 1847555292
Size: 17,82 MB
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Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Radical And Radical Ion Reactivity In Nucleic Acid Chemistry

Author: Michael D. Greenberg
Editor: John Wiley & Sons
ISBN: 0470526262
Size: 11,29 MB
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Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates. With contributions by world leaders in the field, the text covers a broad range of topics, including: A discussion of the relevant theory Ionization of DNA Nucleic acid sugar radicals Halopyrimidines Oxidative, reductive, and low energy electron transfer Electron affinity sensitizers Photochemical generative of reactive oxygen species Reactive nitrogen species Enediyne rearrangements Phenoxyl radicals A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.