Adeno Associated Virus Vectors

Author: Michael J. Castle
Editor: Humana Press
ISBN: 9781493991389
File Size: 79,34 MB
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This volume provides a complete and timely guide to the use of adeno-associated virus (AAV) vectors for genetic manipulation of mammalian tissues. Beginning with methods for the design and characterization of AAV vectors, the book continues with protocols for AAV delivery to various components of the central nervous system, to a number of sensory systems, and to a broad range of other tissues. Novel techniques such as ultrasound-targeted delivery to the brain, subpial delivery to the spinal cord, and subILM delivery to the retina are accompanied by chapters that provide an overview and comparison of current methods for AAV delivery to tissues such as brain, heart, liver, and lung. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible step-by-step laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Adeno-Associated Virus Vectors: Design and Delivery aims to enhance the utility of AAV vectors for targeted gene transfer to living animals and continue the ongoing development of novel AAV-based gene therapies for human disease.
Adeno-Associated Virus Vectors
Language: en
Pages: 426
Authors: Michael J. Castle
Categories: Medical
Type: BOOK - Published: 2019-02-20 - Publisher: Humana Press

This volume provides a complete and timely guide to the use of adeno-associated virus (AAV) vectors for genetic manipulation of mammalian tissues. Beginning with methods for the design and characterization of AAV vectors, the book continues with protocols for AAV delivery to various components of the central nervous system, to
Viral Vectors for Gene Therapy
Language: en
Pages: 450
Authors: Otto-Wilhelm Merten, Mohamed Al-Rubeai
Categories: Medical
Type: BOOK - Published: 2016-08-23 - Publisher: Humana Press

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for
Adeno-Associated Virus (AAV) Vectors in Gene Therapy
Language: en
Pages: 173
Authors: Kenneth I. Berns, Catherine Giraud
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good
Combinatorial Engineering of Adeno Associated Virus Vectors
Language: en
Pages: 105
Authors: Stephan Märsch
Categories: Medical
Type: BOOK - Published: 2009 - Publisher:

Books about Combinatorial Engineering of Adeno Associated Virus Vectors
Adeno-associated Virus Vectors for Gene Therapy
Language: en
Pages: 294
Authors: Stephan Märsch
Categories: Science
Type: BOOK - Published: 2005-11-11 - Publisher: Elsevier Science

Written by well-known experts in the field, this is a timely update on Adeno-associated virus used in gene therapy. The 10 chapters cover gene therapy in specific diseases such as hemophilia, kidney diseases, and disordes of the central nervous system. *Presents a timely update of gene therapy using the adeno-associated