Aluminum And Renal Failure

Author: M.E. de Broe
Editor: Springer Science & Business Media
ISBN: 9400918682
File Size: 64,61 MB
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Increasing the accumulation of aluminum in the bone (body) in cases of renal osteodystrophy may influence the histopathologic aspect of the bones. Alumi num blunts the effect of increased PTH secretion and favours the genesis of osteoid. That means, in cases of renal failure combined with aluminum accumulation, a relatively low bone tunover is found and no fibrosis of the bone marrow. Furthermore the amount of osteoid is increased. This means that there is evidence of osteomalacia especially when the latter is defined as an increased amount of osteoid covered with a relatively low number of cubic osteoblasts. To a certain extent the effect of aluminum accumulation is comparable to the effect of PTX. Treatment with DFO may normalize the bone, although not necessarily with a concomittant disappearance of alumi num from the bone. The presence of aluminum in the bone can be suggested by routine histologic investigation of the bone and can be made rather probably by the aluminum staining combined with iron-staining, but can only be proven by more advanced techniques like ET AAS and LAMMA. References 1. Boyce BF, Elder HY, Elliot HL, Fogelman I, Gell GS, lunor Bl, Beastall G, Boyle YT, 1982: Hypercaicaemic ostemalacia due to aluminium toxicity. Lancet 6: 1009. 2. Verbueken AH, Visser Wl, Van de Vyver FL, Van Grieken RE, De Broe ME, 1986: The use of laser microprobe mass analysis (LAMMA) to control the staining of aluminum by aurin tricarboxylate (aluminon). Stain Technology 61: 287.
Aluminum and renal failure
Language: en
Pages: 378
Authors: M.E. de Broe, Jack W. Coburn
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Increasing the accumulation of aluminum in the bone (body) in cases of renal osteodystrophy may influence the histopathologic aspect of the bones. Alumi num blunts the effect of increased PTH secretion and favours the genesis of osteoid. That means, in cases of renal failure combined with aluminum accumulation, a relatively
Suki and Massry’s Therapy of Renal Diseases and Related Disorders
Language: en
Pages: 1273
Authors: Wadi N. Suki, Shaul G. Massry
Categories: Medical
Type: BOOK - Published: 2013-06-29 - Publisher: Springer Science & Business Media

The field of renal disease has witnessed a huge increase in new knowledge in the 1990s. Advances in our understanding of the pathogenesis and treatment of this complex group of disorders have been escalating rapidly. This is a third edition of this book, which is intended to provide the physician
Aluminium in Biology and Medicine
Language: en
Pages: 326
Authors: Derek J. Chadwick, Julie Whelan
Categories: Medical
Type: BOOK - Published: 2008-04-30 - Publisher: John Wiley & Sons

Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known to damage animals and plants via acid rain. Examines the chemistry and biology of aluminum compounds focusing on the evidence for and against aluminum's role in Alzheimer's disease.
The Vulnerable Brain and Environmental Risks
Language: en
Pages: 332
Authors: R.L. Isaacson, K.F. Jensen
Categories: Medical
Type: BOOK - Published: 2013-03-07 - Publisher: Springer Science & Business Media

Contributors to this second volume discuss metal and toxicant toxicity, their environmental sources and methods of action, and their regulation by courts and agencies.
Replacement of Renal Function by Dialysis
Language: en
Pages: 1536
Authors: C. Jacobs, C. M. Kjellstrand, Karl-Martin Koch
Categories: Medical
Type: BOOK - Published: 2008-01-22 - Publisher: Springer Science & Business Media

Completely revised edition of a global resource first published in 1978 and previously revised in 1989. Sixty-three contributions are arranged in sections on the pathophysiology of the uremic syndrome--principles and biophysics of dialysis; technology of dialysis and associated methods; quantification and prescription; complications; pharmacological considerations; special clinical situations; organ system