Dna Methylation Epigenetics And Metastasis

Author: Manel Esteller
Editor: Springer Science & Business Media
ISBN: 1402036426
File Size: 34,14 MB
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This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.
DNA Methylation, Epigenetics and Metastasis
Language: en
Pages: 310
Authors: Manel Esteller
Categories: Medical
Type: BOOK - Published: 2006-03-30 - Publisher: Springer Science & Business Media

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour.
Epigenetic Regulation of a Gene, MS-1, in Cells of Different Metastatic Potential
Language: en
Pages:
Authors: Manel Esteller
Categories: Medical
Type: BOOK - Published: 2005 - Publisher:

Breast cancer is the most common malignancy and a major cause of cancer-related death among Canadian women. Although treatment of primary breast tumours is highly successful through surgery, metastatic breast cancer is difficult to treat. Cancer progression and metastasis require the accumulation of numerous genetic and epigenetic alterations. Normal cells
Role of DNA Methylation in Skeletal Metastasis and Bone Remodeling
Language: en
Pages:
Authors: Surabhi Parashar
Categories: Medical
Type: BOOK - Published: 2016 - Publisher:

"Breast and prostate cancer are two most common malignancies associated with skeletal metastasis which affect the quality of life and result in high rate of mortality. Various lifestyle choices, genetic disposition and epigenetic factors can favour the process of cancer initiation and progression. Early detection of epigenetic changes can lead
Epigenetic Mechanisms in Cancer
Language: en
Pages: 392
Authors: Sabita Saldanha
Categories: Medical
Type: BOOK - Published: 2017-11-16 - Publisher: Academic Press

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences
Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell
Language: en
Pages: 79
Authors: Yoshimasa Saito
Categories: Biology (General)
Type: BOOK - Published: 2014-11-10 - Publisher: Frontiers E-books

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine