The Immunoglobulins

Author: Roald Nezlin
Editor: Academic Press
ISBN: 9780080534527
File Size: 53,69 MB
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This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Describes recent reviews on the structure and function of immunoglobulin molecules of various species Summarizes in detail recent findings on the fine structure of the antigen-combining site Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties Presents extensive references and is lavishly illustrated
The Immunoglobulins
Language: en
Pages: 269
Authors: Roald Nezlin
Categories: Science
Type: BOOK - Published: 1998-05-06 - Publisher: Academic Press

This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of
Immunoglobulins
Language: en
Pages: 382
Authors: Gary Litman
Categories: Medical
Type: BOOK - Published: 2012-03-08 - Publisher: Springer

Since the discovery more than thirty years ago that antibody actlvlty could be localized to discrete plasma protein fractions, the study of immunoglobulin struc ture and function has dominated the field of immunochemistry. During this time, sources of homogeneous immunoglobulin molecules have been discovered, the subunit nature of the proteins
Immunoglobulins in Health and Disease
Language: en
Pages: 208
Authors: M. French
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Rapid advances continue to be made in all areas of immunology, not least the biology of the immunoglobulins. This knowledge has resulted in a better understanding of antibody responses and helped to clarify pathogenic mechanisms in many diseases, particularly autoimmune and allergic diseases, as well as expand our comprehension of
The Genetic Markers of Human Immunoglobulins
Language: en
Pages: 154
Authors: Rune E. Grubb
Categories: Science
Type: BOOK - Published: 2012-03-23 - Publisher: Springer

It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms
Molecular Genetics of Immunoglobulin
Language: en
Pages: 244
Authors: F. Calabi, M.S. Neuberger
Categories: Medical
Type: BOOK - Published: 1987-12-01 - Publisher: Elsevier

Our understanding of the molecular genetics of immunoglobulins has been enormously advanced by the application of recombinant DNA technology. This new volume in the popular series New Comprehensive Biochemistry contains eight chapters that draw together reviews summarising the research into immunoglobulins and the arrangement, rearrangement and expression of their gene