The Growth Hormone Insulin Like Growth Factor Axis During Development

Author: Isabel Varela-Nieto
Editor: Springer Science & Business Media
ISBN: 0387262741
File Size: 37,81 MB
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Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.

Insulin Like Growth Factors

Author: Derek LeRoith
Editor: CRC Press
ISBN: 9780849357121
File Size: 27,78 MB
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During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

Current Perspectives On Insulin Like Growth Factor Binding Protein Igfbp Research

Author: Andreas Hoeflich
Editor: Frontiers Media SA
ISBN: 2889457184
File Size: 62,29 MB
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The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are located both intra- and extracellularly. Distinct IGFBP-fragments can even be found in the perinuclear compartment or within the nucleus, where they can impact on gene expression. Several contributions presented in the current Research Topic particularly stress the relevance of structural aspects in IGFBP research. The current lack of comprehensive structural information is dramatically limiting the biomarker potential of particular IGFBPs. Finally, the Research Topic also provides novel functions of the IGFBP family from model organisms, farm animals and humans. Thereby, the biomarker potential not only relates to normal and malignant growth but also to metabolism and animal welfare. One important aim of the Research Topic is to encourage next generation IGFBP research reflecting subject-individual, conditional, and hormonal parameters but also structural aspects of the IGFBPs.

Medical Subject Headings

Author: National Library of Medicine (U.S.)
Editor:
ISBN:
File Size: 75,73 MB
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Journal Of The National Cancer Institute

Author:
Editor:
ISBN:
File Size: 77,17 MB
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Cumulated Index Medicus

Author:
Editor:
ISBN:
File Size: 48,14 MB
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The Insulin Like Growth Factors

Author: Paul N. Schofield
Editor: Oxford University Press, USA
ISBN:
File Size: 11,52 MB
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This book reviews what is known of the structure and function of the IGFs. It covers all aspects of the subject, from the organization of IGF genes, to the clinical implications.

Modern Concepts Of Insulin Like Growth Factors

Author: E. Martin Spencer
Editor: Elsevier Publishing Company
ISBN:
File Size: 49,59 MB
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To address the explosion of new and exciting information on the insulin-like growth factors (IGFs), the Second International Symposium on Insulin-Like Growth Factors/Somatomedins was convened from January 12-16, 1991, in San Francisco, California. This book covers many diverse research areas, fostering communication among specialists from such areas as growth and development, cell physiology, reproductive physiology, nephrology, surgery, molecular genetics, oncology and ophthalmology. More than 45 renowned experts present comprehensive discussions of the major areas of IGF research, reviewing the significant background information, presenting the latest in IGF research, and also recommending nomenclature of IGF genes, transcripts, and binding proteins drawn up by special panels.These recurrent themes are expressed throughout: # The remarkable ability of IGFs to adapt, to acquire new functions in different organ systems, and to facilitate actions of other tropic hormones # Autocrine and Paracrine modes of action # The critical role of the IGF binding proteins in regulating IGF actions and delivery to and from tissue # The unique heterogeneity of IGF mRNAs that potentially offers multiple mechanisms for differential regulation of IGF gene expression.

Insulin Like Growth Factors Somatomedins

Author: E. Martin Spencer
Editor: De Gruyter
ISBN:
File Size: 34,96 MB
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"Satellite symposium to the 11th Congress of the International Diabetes Federation"--Pref.

The Role Of Insulin Like Growth Factors In The Nervous System

Author: Mohan K. Raizada
Editor:
ISBN: 9780897667890
File Size: 64,93 MB
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This volume discusses various aspects of the insulin-like growth factors (IGFs), their binding proteins and receptors. The emphasis is on identification of these important growth factors in the nervous system and their potential role in nervous tissue physiology. The IFGs are compared to other growth factors that are important in the nervous system, including nerve growth factor.

The Insulin Like Growth Factors And Their Regulatory Proteins

Author: Robert C. Baxter
Editor: Elsevier Science & Technology
ISBN:
File Size: 27,20 MB
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This volume presents over 40 papers on IGF research. Topics covered include: growth hormone signalling pathways; IGF gene regulation and IGF receptors; IGFBP regulation and actions; metabolic studies; and clinical applications of IGFs. A number of specific body systems are also covered.

The Role Of The Insulin Like Growth Factor Family In The Nervous System

Author: Hsin-Lin Cheng
Editor:
ISBN:
File Size: 57,67 MB
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Insulin Like Growth Factor I In Tissue Regeneration And Growth Control

Author: Dan Edwall
Editor:
ISBN:
File Size: 46,31 MB
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Growth Hormone And Insulin Like Growth Factor I In Human And Experimental Diabetes

Author: Allan Flyvbjerg
Editor: John Wiley & Sons Incorporated
ISBN:
File Size: 18,21 MB
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Current research indicates that growth factors play a role in the physiological, metabolic, functional and structural changes seen in diabetes. This book combines the latest evidence regarding the effects of growth hormone and insulin-like growth factors in relation to metabolism in this disorder and the development of complications.

Insulin Like Growth Factor Binding Protein Igfbp 5

Author: Yang Zhao
Editor:
ISBN:
File Size: 35,23 MB
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Insulin Like Growth Factor Binding Proteins

Author: Stenvert Drop (L. S.)
Editor:
ISBN:
File Size: 53,98 MB
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Regulation Of Serum Insulin Like Growth Factor Binding Proteins Igfbps In Various Physiological Conditions In Tilapia Oreochromis Mossambicus

Author: Richard Ja Park
Editor:
ISBN:
File Size: 19,44 MB
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The Role Of Insulin Like Growth Factor Binding Protein 3 Igfbp 3 In The Proliferation And Differentiation Of L6 Myogenic Cells And Porcine Embryonic Myogenic Cells Pemc

Author: Gang Xi
Editor:
ISBN:
File Size: 52,10 MB
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