Management Of Breast Cancer In Older Women

Author: Malcolm W. Reed
Editor: Springer
ISBN: 9781848002647
File Size: 32,15 MB
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I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result, she was taking a grand total of 500 mg of capecitabine a day. Yet, her metastatic, ER/PR-negative, Her2-positive breast cancer was undoubtedly responding. Her pain was improving and her chest mass was shrinking, as were her lung metastases... What was the secret of that response? Were Mrs T’s kidneys eli- nating even less drug than predicted by her creatinine clearance? Was her sarcopenia altering drug distribution? Was she absorbing more drug than average? Or was her tumor exquisitely sensitive to fluoropyrimidines? “Physicians,” said Voltaire, “pour drugs they know little for diseases they know even less into patients they know no- ing about.” Medicine has made tremendous progress since the eighteenth century. Yet, there are fields where quite a lot remains to be learned. In developed countries, 25% of breast cancers occur in patients aged 75 years and older. Yet, these patients represent only 4% of the population of traditional clinical trials. That ought to let us wonder how relevant data acquired in patients in their 60s are to a nonagenarian. Fortunately, geriatric oncologists have been stepping up to the task and have gen- ated data to help us to treat such patients.
Management of Breast Cancer in Older Women
Language: en
Pages: 413
Authors: Malcolm W. Reed, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2010-01-12 - Publisher: Springer

I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result,
Management of Breast Cancer in Older Women
Language: en
Pages: 261
Authors: Malcolm Reed, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2019-05-07 - Publisher: Springer

The second, updated edition of Management of Breast Cancer in Older Women offers the reader evidence-based knowledge to support the care of older patients with breast cancer. It presents the most up-to-date research and clinical practice from leading specialists across a range of fields that come into contact with older
Management of Breast Cancer in Older Women
Language: en
Pages: 413
Authors: Malcolm W. Reed, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2010-01-18 - Publisher: Springer Science & Business Media

I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result,
Breast Disease
Language: en
Pages: 934
Authors: Adnan Aydiner, Abdullah İgci, Atilla Soran
Categories: Medical
Type: BOOK - Published: 2016-05-09 - Publisher: Springer

This second volume of the handbook on breast disease provides a comprehensive overview of its clinical management and current therapies. It brings readers up to speed with the latest guidelines and therapeutic regimens in breast cancer and provides and in-depth account of current and new therapeutic approaches. Divided in themed
Management of Gynecological Cancers in Older Women
Language: en
Pages: 409
Authors: Stuart M. Lichtman, Riccardo A. Audisio
Categories: Medical
Type: BOOK - Published: 2013-01-11 - Publisher: Springer Science & Business Media

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older gynecological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North