Perfect Targets

Autore: Rebekah Heinrichs
Editore: AAPC Publishing
ISBN: 9781931282185
Grandezza: 36,63 MB
Formato: PDF, Kindle
Vista: 7416
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A 2002 study from Comprehensive Issues in Pediatric Nursing found that 94 percent of students with Asperger Syndrome face torment from their peers. Indeed, some of their behaviors and characteristics that others see as "different" make many of these children easy targets for frequent and severe bullying. This book takes a frank look at the different types of bullying and what adults must do to curb bullying, helping prevent the often lifelong effects of this behavior on its victims. Practical strategies and solutions at the school, class and individual level are presented.

The Perfect Target

Autore: Jenna Mills
Editore: Silhouette
ISBN: 9781426882647
Grandezza: 60,60 MB
Formato: PDF, Mobi
Vista: 9852
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All Miranda Carrington wanted was to be free from her legendary family's legacy of wealth and power. But even in a little seaside village in Portugal, she could not escape the danger that shadowed her.... Only the sudden, stunning appearance of a dark, mysterious stranger had saved her from the ruthless terrorists stalking her. But was Allessandro Vellenti really the devoted guardian he claimed, or part of the deadly conspiracy swirling around her? She knew she shouldn't trust him--with her life or with her heart. And yet, as she fled with him, she ached to give herself, body and soul, to this man who could be her killer....

A Role For The Let 7 Primary Microrna In Target Gene Recognition And Repression

Autore:
Editore: Stanford University
ISBN:
Grandezza: 38,12 MB
Formato: PDF, Kindle
Vista: 3444
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MicroRNA (miRNA) genes produce three noncoding RNA products: the long primary transcript (pri-miRNA), the ~70 nucleotide pre-miRNA, and the ~22-nt mature miRNA. Only the mature miRNA is considered to be the functional species of a miRNA gene in recognizing cognate target mRNAs and modulating their expression. However, mature miRNAs are processed from the primary transcript through sequential endonucleolytic steps. As a result, the mature miRNA sequence is present in all three RNA products of a miRNA gene. It has thus been intrinsically difficult to determine the contribution of each miRNA gene product to target repression. In fact, direct functional roles for pri- and pre-miRNAs have never been ruled out. Here we show that pri- and pre-miRNAs may not be mere transitory intermediates of mature miRNA biogenesis. We found that ectopic expression of the C. elegans miRNA gene let-7 (cel-let-7) in human culture cells results in the production of truncated pre- and mature miRNAs that lack the first two 5' nucleotides, one of which is the first nucleotide of the miRNA seed region (nucleotide SD1). We found this nucleotide to be required for repression of target reporters by cel-let-7 in these cells, demonstrating that pri-let-7 may have a direct role in target repression. Further, we show that the nucleotide sequence and structure of both the pri-/pre-let-7 loop and stem regions play a key role in miRNA gene function in reporter assays. In vitro and in vivo analyses indicated the significance of these regions may be in the mediation of a physical interaction between pri-let-7 and target RNAs. These observations suggest that regulatory information encoded in the structured pri-miRNAs, but absent from mature miRNAs, could be directly interpreted for target recognition and repression through RNA:RNA interaction. Intriguingly, some mutations in the loop nucleotide sequence also restored processing of the 5' ends of C. elegans pre- and mature let-7 in culture cells, demonstrating that the pri-/pre-miRNA loop region can also regulate the precision of mature miRNA biogenesis. Importantly, in the presence of functional pre- and mature let-7, cel-let-7 activity in target repression consists of both SD1-independent and SD1-dependent components, implying potential contributions by both pri- and mature let-7. Finally, we interrogated the effects of pri-/pre-let-7 loop mutations on their ability to rescue a let-7 loss-of-function mutant phenotype in C. elegans. Our results indicate decreased significance of these parameters in the control of worm vulval development, although context-dependent differences in mature miRNA biogenesis between heterologous culture and live animals may partially explain this discrepancy. Taken together the work presented here reveals a novel layer of regulatory complexity encoded in long primary miRNAs that may have broad implications in understanding the mechanisms by which miRNA genes control target expression.

The Perfect Waltz

Autore: Anne Gracie
Editore: Penguin
ISBN: 9781440625190
Grandezza: 12,71 MB
Formato: PDF, Mobi
Vista: 2388
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Society rogue Sebastian Reyne's search for a practical wife comes to a crashing halt when he dances with the effervescent Hope Merridew--and is seduced into a delicious intrigue of sensuality and desire.

Legislation For Alternative Targets For Monetary Policy

Autore: United States. Congress. House. Committee on Banking, Finance, and Urban Affairs. Subcommittee on Domestic Monetary Policy
Editore:
ISBN:
Grandezza: 67,51 MB
Formato: PDF, ePub, Docs
Vista: 5818
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Practice Makes Perfect

Autore: SIMON. HORSEY
Editore: Lulu.com
ISBN: 0557181364
Grandezza: 79,94 MB
Formato: PDF
Vista: 5552
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Soft Target Hardening

Autore: Jennifer Hesterman
Editore: CRC Press
ISBN: 1482244225
Grandezza: 24,34 MB
Formato: PDF, Docs
Vista: 4794
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Winner of ASIS Internationals 2015 Security Book of the Year AwardTerrorist attacks occur daily and are increasingly being aimed at civilian populations around the world. Battlefield lines have been redrawn to include churches, schools, hospitals, and malls. This breach of moral boundary is shocking and invokes feartwo primary goals of terrorism.

Probabilistic Search For Tracking Targets

Autore: Irad Ben-Gal
Editore: John Wiley & Sons
ISBN: 1118597044
Grandezza: 31,51 MB
Formato: PDF, ePub
Vista: 8128
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Presents a probabilistic and information-theoretic framework for a search for static or moving targets in discrete time and space. Probabilistic Search for Tracking Targets uses an information-theoretic scheme to present a unified approach for known search methods to allow the development of new algorithms of search. The book addresses search methods under different constraints and assumptions, such as search uncertainty under incomplete information, probabilistic search scheme, observation errors, group testing, search games, distribution of search efforts, single and multiple targets and search agents, as well as online or offline search schemes. The proposed approach is associated with path planning techniques, optimal search algorithms, Markov decision models, decision trees, stochastic local search, artificial intelligence and heuristic information-seeking methods. Furthermore, this book presents novel methods of search for static and moving targets along with practical algorithms of partitioning and search and screening. Probabilistic Search for Tracking Targets includes complete material for undergraduate and graduate courses in modern applications of probabilistic search, decision-making and group testing, and provides several directions for further research in the search theory. The authors: Provide a generalized information-theoretic approach to the problem of real-time search for both static and moving targets over a discrete space. Present a theoretical framework, which covers known information-theoretic algorithms of search, and forms a basis for development and analysis of different algorithms of search over probabilistic space. Use numerous examples of group testing, search and path planning algorithms to illustrate direct implementation in the form of running routines. Consider a relation of the suggested approach with known search theories and methods such as search and screening theory, search games, Markov decision process models of search, data mining methods, coding theory and decision trees. Discuss relevant search applications, such as quality-control search for nonconforming units in a batch or a military search for a hidden target. Provide an accompanying website featuring the algorithms discussed throughout the book, along with practical implementations procedures.

Radar Imaging Of Airborne Targets

Autore: Brett Borden
Editore: CRC Press
ISBN: 9781420069006
Grandezza: 78,76 MB
Formato: PDF, ePub, Mobi
Vista: 8826
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Radar-based imaging of aircraft targets is a topic that continues to attract a lot of attention, particularly since these imaging methods have been recognized to be the foundation of any successful all-weather non-cooperative target identification technique. Traditional books in this area look at the topic from a radar engineering point of view. Consequently, the basic issues associated with model error and image interpretation are usually not addressed in any substantive fashion. Moreover, applied mathematicians frequently find it difficult to read the radar engineering literature because it is jargon-laden and device specific, meaning that the skills most applicable to the problem's solution are rarely applied. Enabling an understanding of the subject and its current mathematical research issues, Radar Imaging of Airborne Targets: A Primer for Applied Mathematicians and Physicists presents the issues and techniques associated with radar imaging from a mathematical point of view rather than from an instrumentation perspective. The book concentrates on scattering issues, the inverse scattering problem, and the approximations that are usually made by practical algorithm developers. The author also explains the consequences of these approximations to the resultant radar image and its interpretation, and examines methods for reducing model-based error.

Perfect Target

Autore: Stephanie Newton
Editore: Steeple Hill
ISBN: 1426830424
Grandezza: 69,20 MB
Formato: PDF, ePub
Vista: 5114
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The corpse in her path was Bayley Foster's first warning. The second? A break-in at Bayley's own home! She's certain that the stalker who once tormented her has returned to toy with her again. But has her stalker truly escalated to murder? Her fiercely protective neighbor, police detective Cruse Conyers, is determined to get answers. Even if it takes him into the murky depths of the criminal underworld. What he uncovers adds a terrifying twist to the case that could land both Cruse and Bayley in the cross fire….

Climate Action

Autore: Natalia Marshall
Editore: UNEP/Earthprint
ISBN: 9780955440854
Grandezza: 37,65 MB
Formato: PDF, Kindle
Vista: 2665
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Project supported by many international agencies.

Learning Targets

Autore: Connie M. Moss
Editore: ASCD
ISBN: 1416614818
Grandezza: 25,46 MB
Formato: PDF, ePub, Docs
Vista: 136
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In Learning Targets, Connie M. Moss and Susan M. Brookhart contend that improving student learning and achievement happens in the immediacy of an individual lesson--what they call "today's lesson"—or it doesn't happen at all. The key to making today's lesson meaningful? Learning targets. Written from students' point of view, a learning target describes a lesson-sized chunk of information and skills that students will come to know deeply. Each lesson's learning target connects to the next lesson's target, enabling students to master a coherent series of challenges that ultimately lead to important curricular standards. Drawing from the authors' extensive research and professional learning partnerships with classrooms, schools, and school districts, this practical book - Situates learning targets in a theory of action that students, teachers, principals, and central-office administrators can use to unify their efforts to raise student achievement and create a culture of evidence-based, results-oriented practice. - Provides strategies for designing learning targets that promote higher-order thinking and foster student goal setting, self-assessment, and self-regulation. - Explains how to design a strong performance of understanding, an activity that produces evidence of students' progress toward the learning target. - Shows how to use learning targets to guide summative assessment and grading. Learning Targets also includes reproducible planning forms, a classroom walk-through guide, a lesson-planning process guide, and guides to teacher and student self-assessment. What students are actually doing during today's lesson is both the source of and the yardstick for school improvement efforts. By applying the insights in this book to your own work, you can improve your teaching expertise and dramatically empower all students as stakeholders in their own learning.

Therapeutic Monoclonal Antibodies

Autore: Zhiqiang An
Editore: John Wiley & Sons
ISBN: 1118210263
Grandezza: 70,70 MB
Formato: PDF, ePub, Docs
Vista: 3486
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70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Perfect Dark Initial Vector

Autore: Greg Rucka
Editore: Tor Books
ISBN: 9781429914529
Grandezza: 57,26 MB
Formato: PDF, ePub, Mobi
Vista: 7898
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The year is 2020: Corporations control everything. In the name of domination, these sprawling organizations have recruited their own military forces to fight clandestine battles against one another---a war fought in the boardrooms and won in the shadows, with the public none the wiser. Ex--bounty hunter Joanna Dark has unwillingly seen the front lines of this war. Her run-in with dataDyne, the world's most powerful hypercorporation, has left her with a wound that only vengeance can heal. Daniel Carrington, the charismatic founder of the Carrington Institute, has been locked in an ongoing war with dataDyne for years and sees Joanna's deadly skills as the key to victory over their mutual enemy. But Joanna is young and lost, unable to accept her abilities as virtues or fully trust Carrington's intentions. But when an explosive secret is unearthed---one that could finally bring down the threat of dataDyne once and for all---Joanna finds herself thrust back into the fight, one that brings her face to face with her past . . . and the forces shaping her future. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

The Accidental President

Autore: Harris I. Baseman
Editore: iUniverse
ISBN: 0595755151
Grandezza: 48,77 MB
Formato: PDF
Vista: 4170
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When an explosion rips through the home of Gulf War veteran Clarence Davenport, Secret Service Agent John Wallace and White House aide Molly Pemberton are certain that Davenport, the assassin who killed President Butler, had killed himself. President Silver, the former Education Secretary who became President when Davenport killed all other legal successors to the Presidency, informs the nation that the crime of the century has been solved and that the perpetrator is dead, only to have to admit, days later, that Davenport had escaped. National outrage at Davenport's escape escalates, fueled by Senator Jeb Davies' political ambition and his hatred of Ben Silver. Davenport, the world's most sought after fugitive, with no other place to go, is recruited by Saudi expatriates opposed to the Royal Family and ends up in an Al Qaeda training camp where he devises another plan to kill President Silver and attack the United States. Silver tries to stave off the rising tide of impeachment and at the same time combat the increasing risk of a terrorist attack that will destroy the Presidency and fundamentally change the Unites States unless he can avoid impeachment and intercept the threat. " timely as this evening's news " -Melannie Lauers, Cape Cod Times(on After Kamisiyah) " an intriguing insight " -Mathew Call, Newton Tab (on After Kamisiyah)

Bombing To Win

Autore: Robert A. Pape
Editore: Cornell University Press
ISBN: 0801471508
Grandezza: 34,74 MB
Formato: PDF, ePub, Mobi
Vista: 4682
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From Iraq to Bosnia to North Korea, the first question in American foreign policy debates is increasingly: Can air power alone do the job? Robert A. Pape provides a systematic answer. Analyzing the results of over thirty air campaigns, including a detailed reconstruction of the Gulf War, he argues that the key to success is attacking the enemy's military strategy, not its economy, people, or leaders. Coercive air power can succeed, but not as cheaply as air enthusiasts would like to believe. Pape examines the air raids on Germany, Japan, Korea, Vietnam, and Iraq as well as those of Israel versus Egypt, providing details of bombing and governmental decision making. His detailed narratives of the strategic effectiveness of bombing range from the classical cases of World War II to an extraordinary reconstruction of airpower use in the Gulf War, based on recently declassified documents. In the first major book since the Vietnam War on the theory and practice of airpower and its political effects, Robert A. Pape helps policy makers judge the purpose of various air strategies, and helps general readers understand the policy debates.

A Perfect Moral Storm

Autore: Stephen M. Gardiner
Editore: Oxford University Press
ISBN: 0199910456
Grandezza: 14,38 MB
Formato: PDF, ePub
Vista: 5768
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Climate change is arguably the great problem confronting humanity, but we have done little to head off this looming catastrophe. In The Perfect Moral Storm, philosopher Stephen Gardiner illuminates our dangerous inaction by placing the environmental crisis in an entirely new light, considering it as an ethical failure. Gardiner clarifies the moral situation, identifying the temptations (or "storms") that make us vulnerable to a certain kind of corruption. First, the world's most affluent nations are tempted to pass on the cost of climate change to the poorer and weaker citizens of the world. Second, the present generation is tempted to pass the problem on to future generations. Third, our poor grasp of science, international justice, and the human relationship to nature helps to facilitate inaction. As a result, we are engaging in willful self-deception when the lives of future generations, the world's poor, and even the basic fabric of life on the planet is at stake. We should wake up to this profound ethical failure, Gardiner concludes, and demand more of our institutions, our leaders and ourselves. "This is a radical book, both in the sense that it faces extremes and in the sense that it goes to the roots." --Notre Dame Philosophical Reviews "The book's strength lies in Gardiner's success at understanding and clarifying the types of moral issues that climate change raises, which is an important first step toward solutions." --Science Magazine "Gardiner has expertly explored some very instinctual and vitally important considerations which cannot realistically be ignored. --Required reading." --Green Prophet "Gardiner makes a strong case for highlighting and insisting on the ethical dimensions of the climate problem, and his warnings about buck-passing and the dangerous appeal of moral corruptions hit home." --Times Higher Education "Stephen Gardiner takes to a new level our understanding of the moral dimensions of climate change. A Perfect Moral Storm argues convincingly that climate change is the greatest moral challenge our species has ever faced - and that the problem goes even deeper than we think." --Peter Singer, Princeton University

Trading On Target

Autore: Adrienne Toghraie
Editore: John Wiley & Sons
ISBN: 1118086775
Grandezza: 78,75 MB
Formato: PDF, Docs
Vista: 1189
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A leading trainer of traders explains the process and pitfalls to trading success While advances in trading tools and technology have increased the potential for capturing profits, the fact is that if you're mentally unprepared to enter today's markets, you'll probably end up making many costly mistakes. Nobody understands this better than Adrienne Toghraie, an expert Trader's Success Coach and master practitioner of Neuro-Linguistic Programming (NLP) for the financial and business communities. Now, with Trading on Target, she shares her extensive experiences—as well as the stories of real-world traders—to help you overcome the self-imposed limitations keeping you from reaching trading success. Engaging and informative, this accessible guide takes a detailed look at what you need to become a psychologically, and emotionally, mature trader. Page by page, Toghraie pulls it all together and reveals the attitudes, perceptions, and insights that will allow you to excel at this difficult endeavor. Along the way, she also provides practical solutions to dealing with the oldest hang-ups commonly found among those who aspire to succeed in trading, and offers advice on how to gain and maintain self-discipline in today's dynamic markets. Shows how to overcome the various obstacles to becoming a top trader Explores how you can let go of emotional states that can affect your trading Offers insights on taking the right action and making better trading decisions Reveals how to expand yourself in order to reach the next level of trading success Wherever you are in your ability as a trader, there is always room to grow. Adrienne Toghraie has seen this firsthand during her twenty-one years in the business of working on trader discipline. With this book, she'll help you develop a winning trading mindset and put you in a better position to break through the barriers that have been holding you back.

Hardware And Housefurnishing Goods

Autore:
Editore:
ISBN:
Grandezza: 72,56 MB
Formato: PDF, Mobi
Vista: 9136
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Analysis Of Biomarker Data

Autore: Stephen W. Looney
Editore: John Wiley & Sons
ISBN: 1118552458
Grandezza: 18,72 MB
Formato: PDF, ePub, Mobi
Vista: 3849
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A “how to” guide for applying statistical methods to biomarker data analysis Presenting a solid foundation for the statistical methods that are used to analyze biomarker data, Analysis of Biomarker Data: A Practical Guide features preferred techniques for biomarker validation. The authors provide descriptions of select elementary statistical methods that are traditionally used to analyze biomarker data with a focus on the proper application of each method, including necessary assumptions, software recommendations, and proper interpretation of computer output. In addition, the book discusses frequently encountered challenges in analyzing biomarker data and how to deal with them, methods for the quality assessment of biomarkers, and biomarker study designs. Covering a broad range of statistical methods that have been used to analyze biomarker data in published research studies, Analysis of Biomarker Data: A Practical Guide also features: A greater emphasis on the application of methods as opposed to the underlying statistical and mathematical theory The use of SAS®, R, and other software throughout to illustrate the presented calculations for each example Numerous exercises based on real-world data as well as solutions to the problems to aid in reader comprehension The principles of good research study design and the methods for assessing the quality of a newly proposed biomarker A companion website that includes a software appendix with multiple types of software and complete data sets from the book’s examples Analysis of Biomarker Data: A Practical Guide is an ideal upper-undergraduate and graduate-level textbook for courses in the biological or environmental sciences. An excellent reference for statisticians who routinely analyze and interpret biomarker data, the book is also useful for researchers who wish to perform their own analyses of biomarker data, such as toxicologists, pharmacologists, epidemiologists, environmental and clinical laboratory scientists, and other professionals in the health and environmental sciences.