Postgenomics

Author: Sarah S. Richardson
Editor:
ISBN: 9780822359227
File Size: 16,96 MB
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The contributors to Postgenomics assess the changes to the life sciences the Human Genome Project's completion brought, develop new frameworks for studying the human genome in the postgenomic era, and show how the environment, technology, race, and gender influence the genome and how we think about it.

Probabilistic Graphical Models For Genetics Genomics And Postgenomics

Author: Christine Sinoquet
Editor: Oxford University Press, USA
ISBN: 0198709021
File Size: 63,71 MB
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At the crossroads between statistics and machine learning, probabilistic graphical models provide a powerful formal framework to model complex data. For instance, Bayesian networks and Markov random fields are two of the most popular probabilistic graphical models. With the rapid advance of high-throughput technologies and their ever decreasing costs, a fast-growing volume of biological data of various types - the so-called ''omics'' - is in need of accurate andefficient methods for modeling, prior to further downstream analysis. As probabilistic graphical models are able to deal with high-dimensional data, it is foreseeable that such models will have aprominent role to play in advances in genome-wide data analyses. Currently, few people are specialists in the design of cutting-edge methods using probabilistic graphical models for genetics, genomics and postgenomics. This seriously hinders the diffusion of such methods. The prime aim of the book is therefore to bring the concepts underlying these advanced models within reach of scientists who are not specialists of these models, but with no concession on theinformativeness of the book. The target readers include researchers and engineers who have to design novel methods for postgenomics data analysis, as well as graduate students starting a Masters or a PhD. Inaddition to an introductory chapter on probabilistic graphical models, a thorough review chapter focusing on selected domains in genetics and fourteen chapters illustrate the design of such advanced approaches in various domains: gene network inference, inference of causal phenotype networks, association genetics, epigenetics, detection of copy number variations, and prediction of outcomes from high-dimensional genomic data. Notably, most examples also illustrate that probabilistic graphicalmodels are well suited for integrative biology and systems biology, hot topics guaranteed to be of lasting interest.

Obesity

Author: Karine Clement
Editor: CRC Press
ISBN: 9781420020137
File Size: 27,37 MB
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This book comprehensively accounts the current understanding of genetic mechanisms of obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and mutations, and current results from animal model research and genetic studies in human models. By presenting the impact of genetic factors in the development of obesity and key molec

The Gene

Author: Hans-Jörg Rheinberger
Editor: University of Chicago Press
ISBN: 022647478X
File Size: 55,55 MB
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Few concepts played a more important role in twentieth-century life sciences than that of the gene. Yet at this moment, the field of genetics is undergoing radical conceptual transformation, and some scientists are questioning the very usefulness of the concept of the gene, arguing instead for more systemic perspectives. The time could not be better, therefore, for Hans-Jörg Rheinberger and Staffan Müller-Wille's magisterial history of the concept of the gene. Though the gene has long been the central organizing theme of biology, both conceptually and as an object of study, Rheinberger and Müller-Wille conclude that we have never even had a universally accepted, stable definition of it. Rather, the concept has been in continual flux—a state that, they contend, is typical of historically important and productive scientific concepts. It is that very openness to change and manipulation, the authors argue, that made it so useful: its very mutability enabled it to be useful while the technologies and approaches used to study and theorize about it changed dramatically.

Rethinking Cancer

Author: Bernhard Strauss
Editor: MIT Press
ISBN: 0262362082
File Size: 61,86 MB
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Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Rethinking Cancer

Author: Bernhard Strauss
Editor: MIT Press
ISBN: 0262045214
File Size: 71,50 MB
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"Steps toward an explanatory paradigm for cancer that integrates its different levels of organization (molecular, genetic, etc.) and also integrates theoretical and experimental biology with oncology"--

Obesity

Author: Karine Clément
Editor:
ISBN: 9780429117985
File Size: 22,96 MB
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Annual Review Of Anthropology

Author:
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ISBN:
File Size: 62,31 MB
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Annual compilation of critical articles from all areas of the discipline of anthropology.

Integrative Physiology In The Proteomics And Post Genomics Age

Author: Wolfgang Walz
Editor: Springer Science & Business Media
ISBN: 1592599257
File Size: 50,53 MB
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There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

Gene Regulation And Metabolism

Author: Julio Collado-Vides
Editor: Bradford Book
ISBN: 9780262270649
File Size: 37,88 MB
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An overview of current computational approaches to metabolism and gene regulation.

New Scientist

Author:
Editor:
ISBN:
File Size: 70,48 MB
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Bioinformatics

Author: Frédéric Dardel
Editor: John Wiley & Sons
ISBN: 9780470020029
File Size: 52,51 MB
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This book is an excellent introductory text describing the use of bioinformatics to analyze genomic and post-genomic data. It has been translated from the original popular French edition, which was based on a course taught at the well-respected École Polytechnique in Palaiseau. This edition has been fully revised and updated by the authors. After a brief introduction to gene structure and sequence determination, it describes the techniques used to identify genes, their protein-coding sequences and regulatory regions. The book discusses the methodology of comparative genomics, using information from different organisms to deduce information about unknown sequences. There is a comprehensive chapter on structure prediction, covering both RNA and protein. Finally, the book describes the complex networks of RNA and protein that exist within the cell and their interactions, ending with a discussion of the simulation approaches that can be used to model these networks. Praise from the reviews: “In context of the new developments the genomic era has brought, Bioinformatics: Genomics and Post-Genomics becomes a fundamental and indispensable resource for undergraduate and early graduate students...insightfully authored...will immensely help students...in establishing important foundations while shaping their careers.” NEWSLETTER, BRITISH SOCIETY OF CELL BIOLOGY

Philosophia Naturalis

Author:
Editor:
ISBN:
File Size: 44,97 MB
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Proceedings Of The 9th International Congress On Obesity

Author: Geraldo Medeiros-Neto
Editor: John Libbey Eurotext
ISBN: 9782742004607
File Size: 43,13 MB
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Obesity is officially recognised as a major worldwide public health problem. "Progress in Obesity Research: 9" fulfils the need for an accessible and fundamental research, highly recommended towards a better understanding of obesity. It will prove an indispensable resource for all those involved in the research, prevention and treatment of obesity.

Sulfur Transport And Assimilation In Plants

Author: Jean-Claude Davidian
Editor:
ISBN:
File Size: 51,45 MB
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This book contains the invited and contributed papers of the 5th Workshop on Sulfur Transport and Assimilation in Plants, a joined European Commission (COST Action 829) and OECD meeting hosted at the Ecole Nationale Supérieure Agronomique in Montpellier (France) from April 11 to 14, 2002. The meeting was co-organized by the ENSA-Montpellier (France), the University of Graz (Austria), the University of Groningen (The Netherlands), Rothamsted Research, (United Kingdom), Institute of Plant Nutrition and Soil Science, Braunschweig (Germany), the Agricultural Biotechnical Center of Gödöllö (Hungary), Albert-Ludwigs-University Freiburg (Germany) and the University of Chiba (Japan).

Human Development

Author: Karen L. Freiberg
Editor: McGraw-Hill/Dushkin
ISBN: 9780070413658
File Size: 66,40 MB
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The Philosopher S Index

Author:
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ISBN:
File Size: 23,57 MB
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Vols. for 1969- include a section of abstracts.

Bioinformatics In The Era Of Post Genomics And Big Data

Author: Ibrokhim Y. Abdurakhmonov
Editor: BoD – Books on Demand
ISBN: 1789232686
File Size: 65,27 MB
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Bioinformatics has evolved significantly in the era of post genomics and big data. Huge advancements were made toward storing, handling, mining, comparing, extracting, clustering and analysis as well as visualization of big macromolecular data using novel computational approaches, machine and deep learning methods, and web-based server tools. There are extensively ongoing world-wide efforts to build the resources for regional hosting, organized and structured access and improving the pre-existing bioinformatics tools to efficiently and meaningfully analyze day-to-day increasing big data. This book intends to provide the reader with updates and progress on genomic data analysis, data modeling and network-based system tools.

Phytochemistry In The Genomics And Post Genomics Eras

Author: John Romeo
Editor: Elsevier
ISBN: 9780080538983
File Size: 80,96 MB
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This monograph series is commissioned by the Phytochemical Society of North America (PSNA). The volumes in this series contain articles on developing topics of interest to scientists, students and individuals interested in recent developments in the biochemistry, chemistry and molecular biology of plants. Volume 36 centers on the role of phytochemistry in the rapid developments in biology brought about by the application of large-scale genomics approaches. Several functional genomic approaches discussed in this volume address plant gene function on a large scale. Plants are combinatorial chemists par excellence, and understanding the principles that relate enzyme structure to function will open up unlimited possibilities for the rational design of new enzymes to generate novel biologically active natural products. Knowledge of the molecular genetics of plant natural product pathways will also facilitate the engineering of these pathways for plant improvement and human benefit. Phytochemistry truly has a great future in the genomics and post-genomics eras.

Defining The Mandate Of Proteomics In The Post Genomics Era

Author: Board on International Scientific Organizations
Editor: National Academies Press
ISBN: 030954226X
File Size: 60,96 MB
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Research in proteomics is the next logical step after genomics in understanding life processes at the molecular level. In the largest sense proteomics encompasses knowledge of the structure, function and expression of all proteins in the biochemical or biological contexts of all organisms. Since that is an impossible goal to achieve, at least in our lifetimes, it is appropriate to set more realistic, achievable goals for the field. Up to now, primarily for reasons of feasibility, scientists have tended to concentrate on accumulating information about the nature of proteins and their absolute and relative levels of expression in cells (the primary tools for this have been 2D gel electrophoresis and mass spectrometry). Although these data have been useful and will continue to be so, the information inherent in the broader definition of proteomics must also be obtained if the true promise of the growing field is to be realized. Acquiring this knowledge is the challenge for researchers in proteomics and the means to support these endeavors need to be provided. An attempt has been made to present the major issues confronting the field of proteomics and two clear messages come through in this report. The first is that the mandate of proteomics is and should be much broader than is frequently recognized. The second is that proteomics is much more complicated than sequencing genomes. This will require new technologies but it is highly likely that many of these will be developed. Looking back 10 to 20 years from now, the question is: Will we have done the job wisely or wastefully?