Randomised Clinical Trials

Author: David Machin
Editor: John Wiley & Sons
ISBN: 1119524644
File Size: 68,94 MB
Format: PDF
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Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process. This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book: Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced Features several new chapters, updated case studies and examples, and references to changes in regulations Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure Covers paired trial designs and trials with more than two interventions Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.
Randomised Clinical Trials
Language: en
Pages: 560
Authors: David Machin, Peter M. Fayers, Bee Choo Tai
Categories: Medical
Type: BOOK - Published: 2021-08-09 - Publisher: John Wiley & Sons

Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and
Randomised Controlled Clinical Trials
Language: en
Pages: 262
Authors: Christopher J. Bulpitt
Categories: Medical
Type: BOOK - Published: 2013-03-08 - Publisher: Springer

Bradford Hill has defined a clinical trial as "A carefully and ethically designed experiment with the aim of answering some precisely framed question" [1]. This definition specifies a careful design and requires the provision of adequate controls. Random allocation of treatments to subjects is important to ensure is entitled that
Introduction to Randomized Controlled Clinical Trials, Second Edition
Language: en
Pages: 304
Authors: John N.S. Matthews
Categories: Mathematics
Type: BOOK - Published: 2006-06-26 - Publisher: Chapman and Hall/CRC

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials
Randomized Clinical Trials
Language: en
Pages: 374
Authors: David Machin, Peter M. Fayers
Categories: Medical
Type: BOOK - Published: 2010-05-20 - Publisher: John Wiley & Sons

Using examples and case studies from industry, academia and research literature, Randomized Clinical Trials provides a detailed overview of the key issues involved in designing, conducting, analysing and reporting randomized clinical trials. It examines the methodology for conducting Phase III clinical trials, developing the protocols, the practice for capturing, measuring,
Randomised Controlled Clinical Trials
Language: en
Pages: 262
Authors: Christopher Bulpitt
Categories: Medical
Type: BOOK - Published: 1983 - Publisher: Springer

This is the first book on randomised controlled trials (RCTs) that attempts to deal with all aspects of trial design and execution. The text is primarily intended for research workers in the medical field, but scientists involved in any randomised trial should find the book of assistance. The first chapters