Randomised Controlled Clinical Trials

Author: Christopher J. Bulpitt
Editor: Springer
ISBN: 9781475763607
File Size: 31,24 MB
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Bradford Hill has defined a clinical trial as "A carefully and ethically designed experiment with the aim of answering some precisely framed question" [1]. This definition specifies a careful design and requires the provision of adequate controls. Random allocation of treatments to subjects is important to ensure is entitled that the treated and control groups are similar. Therefore this book Randomised Controlled Clinical Trials. We can define a randomised controlled trial by rewriting Bradford Hill's definition as follows, "A carefully and ethi cally designed experiment which includes the provision of adequate and ap propriate controls by a process of randomisation, so that precisely framed questions can be answered. " I am a firm advocate ofRandomised Controlled Clinical Trials but intend to give a balanced view of the advantages and disadvantages of these ethical experiments. This book is directed primarily at the medical research worker, although certain chapters may find a wider application. When discussing a randomised controlled trial, it is neither practicable nor desirable to divorce theory from practice, however the first ten chapters con centrate mainly on theory, and the remainder focus on practice. The segment on trial design is followed by sections on writing the protocol, designing the forms, conducting the trial, and analysing the results. This book is meant to serve both as a reference manual and a practical guide to the design and performance of a trial.
Randomised Controlled Clinical Trials
Language: en
Pages: 262
Authors: Christopher J. Bulpitt
Categories: Medical
Type: BOOK - Published: 2013-03-08 - Publisher: Springer

Bradford Hill has defined a clinical trial as "A carefully and ethically designed experiment with the aim of answering some precisely framed question" [1]. This definition specifies a careful design and requires the provision of adequate controls. Random allocation of treatments to subjects is important to ensure is entitled that
Randomised Controlled Clinical Trials
Language: en
Pages: 262
Authors: Christopher Bulpitt
Categories: Medical
Type: BOOK - Published: 1983 - Publisher: Springer

This is the first book on randomised controlled trials (RCTs) that attempts to deal with all aspects of trial design and execution. The text is primarily intended for research workers in the medical field, but scientists involved in any randomised trial should find the book of assistance. The first chapters
Randomized Controlled Trials
Language: en
Pages: 160
Authors: Alehandro R. Jadad, Murray W. Enkin
Categories: Medical
Type: BOOK - Published: 2008-04-15 - Publisher: John Wiley & Sons

Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clinical decision-making. Structured in a jargon-free question-and-answer format, each chapter provides concise and understandable
Introduction to Randomized Controlled Clinical Trials, Second Edition
Language: en
Pages: 304
Authors: John N.S. Matthews
Categories: Mathematics
Type: BOOK - Published: 2006-06-26 - Publisher: Chapman and Hall/CRC

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials
Introduction to Randomized Controlled Clinical Trials
Language: en
Pages: 302
Authors: John N.S. Matthews
Categories: Mathematics
Type: BOOK - Published: 2006-06-26 - Publisher: CRC Press

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials