Regulation Of Isopentenoid Metabolism

Author: W. David Nes
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ISBN:
File Size: 28,69 MB
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Presents the current state of isopentenoid metabolism in plants, animals, and insects. Illustrates cross-disciplinary research efforts by the medical and agricultural communities to solve common problems regarding the regulation of the isopentenoid pathway. Addresses the rational design of potent inhibitors specific to different regulatory steps. Examines the chemical, biochemical, and molecular biological mechanisms that regulate the pathway. Covers newly emerging areas, including prenylated proteins and cancer, carotenoids and biotechnology, sterol homeostasis, and molecular biology.

Regulation Of Plant Isoprenoid Metabolism

Author: Doil Choi
Editor:
ISBN:
File Size: 22,52 MB
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Research Awards Index

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File Size: 33,30 MB
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Isopentenoids And Other Natural Products

Author: W. David Nes
Editor: Amer Chemical Society
ISBN:
File Size: 13,43 MB
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Describes the evolution of pathway sequencing of natural products. Critically examines the selection pressures that influenced change in the structure of natural products. Addresses the structure and stereochemistry of a range of natural products, including isopentenoids, sterols, triterpenes, lignins, and fatty acids. Examines the geochemistry and biochemistry of isopentenoids. Also examines function in relation to biosynthesis of natural products.

Cellulose Chemistry And Technology

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File Size: 44,60 MB
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Anticancer Research

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File Size: 36,93 MB
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Regulation Of Cholesterol And Isoprenoid Biosynthesis

Author: David Lyle Bradfute
Editor:
ISBN:
File Size: 79,62 MB
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Proceedings Of The International Symposium On Medicinal And Aromatic Plants August 27 30 1995 Amherst Ma Usa

Author: Lyle E. Craker
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ISBN:
File Size: 74,92 MB
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Directory Of Published Proceedings

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File Size: 24,29 MB
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Intermediary Metabolism And Its Regulation

Author: Joseph Larner
Editor: Prentice Hall
ISBN:
File Size: 49,88 MB
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Protein Topology And Subcellular Localization Of The Isoprenoid Biosynthetic Enzyme 3 Hydroxy 3 Methylglutaryl Coenzyme A Reductase

Author: Edward Brian Re
Editor:
ISBN:
File Size: 42,61 MB
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Biochemistry Of Steroids And Other Isopentenoids

Author: William R. Nes
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File Size: 16,55 MB
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Annual Report

Author: Scottish Crop Research Institute
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File Size: 43,79 MB
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Models In Plant Physiology And Biochemistry

Author: David W. Newman
Editor: CRC
ISBN:
File Size: 42,17 MB
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Regulation Of Membrane Lipid Metabolism

Author: Guy A. Thompson
Editor: Springer
ISBN:
File Size: 24,82 MB
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Summarizes the current knowledge on the metabolism of membrane lipids, emphasizing the regulatory interactions. Somewhere between a general textbook and a comprehensive review article, for students who want to apply their learning from a basic biochemistry course to problems involving membranes. Also useful to researchers in related fields, whose work sometimes involves membranes. Extensively updated from the 1980 edition. Annotation copyrighted by Book News, Inc., Portland, OR

Public Health Service Grants And Awards 1973 Pt 1 Publ 1973

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Role Of Peroxisomes In Isoprenoid Biosynthesis

Author: Nahla Mohamed Aboushadi
Editor:
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File Size: 63,31 MB
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Our group has demonstrated that all the enzymes required for the biosynthesis of farnesyl diphosphate (FPP) from mevalonate are localized to peroxisomes. FPP is the precursor of critical isoprenoids, thus, its regulation and metabolism are crucial. In rat liver, an allyl pyrophosphatase (FPPase) converts FPP to free farnesol. Farnesol is then oxidized to prenyl aldehyde by alcohol dehydrogenase (ADH) or it is converted to FPP by phosphorylation reactions. In this study, we identified a specific FPP kinase activity in rat liver. We also determined the subcellular localization of the FPPase, ADK and FPP kinase activities in whole liver homogenates. Regulation studies demonstrated that FPP kinase activity but not FPPase responded to modulation in FPP levels. The rate-limiting enzyme in isoprenoid biosynthesis, 3-Hydroxy-3-methylglutaryl (HMG)-CoA reductase has been localized to peroxisomes and endoplasmic reticulum (ER). No information is available regarding the regulation or function of the peroxisomal reductase in isoprenoid metabolism. To facilitate the regulation studies of the peroxisomal reductase, we utilized a mammalian cell line (UT2*) that expresses only one reductase protein of 90 kDa that is localized exclusively in peroxisomes. Comparison of the regulation of the two reductases revealed major differences between the two proteins. The peroxisomal reductase is not the rate-limiting enzyme for cholesterol biosynthesis. The peroxisomal protein is not phosphorylated and its activity is not altered in the presence of cellular phosphatases. Its rate of degradation is not accelerated by mevalonate. Moreover, the degradation process is not blocked by the cysteine protease/proteosome inhibitor, N-acetyl-Leu-Leu-norleucinal (ALLN). Finally, the peroxisomal protein is more resistant to statin inhibition. These data suggest that the peroxisomal protein is functionally and structurally different from the ER reductase. We also showed that peroxisomal-deficient PEX2- Chinese hamster ovary (CHO) cells display reduced levels of peroxisomal. isoprenoid enzymes and show reduced rates of isoprenoid biosynthesis. We showed that the deficiency in the peroxisomal enzymes was due to acceleration in the rate of degradation of the proteins, and a decrease in the mRNA levels and rate of synthesis of these proteins. Taken together, the data presented in this study emphasize the indispensable role of peroxisomes in isoprenoid biosynthesis.

Isoprenoid Synthesis In Plants And Microorganisms

Author: Thomas J. Bach
Editor: Springer Science & Business Media
ISBN: 1461440637
File Size: 20,11 MB
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Isoprenoids are important in primary and secondary metabolism. They have implications in a myriad of physiological processes notably in plants, microorganisms and parasites, and biological activities at the cellular, organism, and ecosystem levels. The importance of isoprenoids in various areas of the scientific world has spurred intense research worldwide. Also their role in "nutraceuticals" has stimulated scientific curiosity. Literature on isoprenoids is widely scattered in journals with quite differing readerships and geographic distribution. A comprehensive book on isoprenoids does not exist. Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches fills this gap by presenting the latest and the most applicable information on isoprenoids. The most recent TERPNET conference serves as the backdrop and provides much of the inspiration for the topics covered in the book. Additional topics of interest are covered as well, making Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches the most comprehensive review of isoprenoid synthesis to date.