Schwann Spectrum

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Spectrum

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File Size: 40,28 MB
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Schwann Spectrum

Author: Schwann Publications
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ISBN: 9781575980034
File Size: 25,39 MB
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Continued Learning Of Tissue Specific Immunity From The Immuno Pathological Spectrum Of Leprosy

Author: Pranab Kumar Das
Editor: Frontiers Media SA
ISBN: 2889634205
File Size: 24,53 MB
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Leprosy is one of the oldest recorded debilitating diseases affecting mankind, the immunopathology of which is characterized by fluctuating granulomatous inflammation that targets mainly skin and peripheral nerve. The disease is caused by infection with Mycobacterium leprae, a slow growing obligatory intracellular and non-cultivatable organism. The disease is manifested with diverse pathology due to varied immune (both innate and adaptive) responses of the hosts as a result of cognate interaction with the organism. Of note, leprosy can be regarded as a unique model to elucidate the complexity of host immunity at both skin and systemic levels.

The British Union Catalogue Of Music Periodicals

Author: John Wagstaff
Editor: Routledge
ISBN: 0429802617
File Size: 34,13 MB
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First published in 1998, the aim of this catalogue is to help students, researchers and librarians determine the UK locations of over 2,000 music periodical titles held in public, academic and national libraries. Over 220 libraries in the UK have been surveyed, from St. Austell to Aberdeen, Aberystwyth to Brighton. Each catalogue entry provides detailed information on library holdings, and full bibliographic details of periodical titles, including ISSNs. The main catalogue is preceded by an address list, and by a preface outlining the history of music periodicals in Britain, together with statistical tables.

Fundamentals Of Collection Development Management

Author: Peggy Johnson
Editor: American Library Association
ISBN: 9780838908532
File Size: 69,24 MB
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Taking a fresh approach, this comprehensive guide outlines the step-by-step process of collection development and management. Expert librarian Peggy Johnson offers tips for organizing and staffing, conceiving policy and creating budgets, and developing, marketing and evaluating collections.

Reference Sources For Small And Medium Sized Libraries

Author: Scott Kennedy
Editor: American Library Association
ISBN: 9780838934685
File Size: 67,82 MB
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An annotated bibliography lists reference sources for those academic and public libraries that can't buy everything but want the best for their patrons

Library Acquisition Of Music

Author: Robert Michael Fling
Editor: Scarecrow Press
ISBN: 9780810851245
File Size: 11,26 MB
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Provides advice for libraries on acquiring printed and recorded music; including information on preordering, the ordering process, secondhand and out of print materials, and more.

Annual Report Of The Board Of Regents Of The Smithsonian Institution

Author: Smithsonian Institution. Board of Regents
Editor:
ISBN:
File Size: 52,91 MB
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Annual Report Of The Board Of Regents Of The Smithsonian Institution

Author: Smithsonian Institution
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ISBN:
File Size: 30,13 MB
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Abstracts Of The Papers Communicated To The Royal Society Of London

Author: Royal Society (Great Britain)
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ISBN:
File Size: 55,86 MB
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Index To Foreign Scientific Periodicals Contained In The Patent Office Library

Author: Great Britain. Patent Office. Library
Editor:
ISBN:
File Size: 16,72 MB
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Catalogue Of The Special Loan Collection Of Scientific Apparatus At The South Kensington Museum

Author: South Kensington Museum London
Editor:
ISBN:
File Size: 42,89 MB
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Abstracts Of The Papers Printed In The Philosophical Transactions Of The Royal Society Of London

Author: Royal Society (Great Britain)
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ISBN:
File Size: 11,34 MB
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Catalogue Of The General And Law Library

Author: Tennessee. State Library
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ISBN:
File Size: 69,27 MB
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Nature

Author: Sir Norman Lockyer
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ISBN:
File Size: 74,67 MB
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How To Work With The Microscope

Author: Lionel Smith Beale
Editor:
ISBN:
File Size: 55,40 MB
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Proceedings Of The Royal Society Of London

Author: Royal Society (Great Britain)
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ISBN:
File Size: 40,92 MB
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Report Of The Meeting Of The British Association For The Advancement Of Science

Author: British Association for the Advancement of Science. Meeting
Editor:
ISBN:
File Size: 17,95 MB
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Engineering Optogentically Controlled Schwann Cells

Author: Tasneem Hassan Muna
Editor:
ISBN:
File Size: 52,77 MB
Format: PDF
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Spinal cord injury (SCI) affects millions of people worldwide. It is a complicated disease with no cure that leaves patients with permanent neurological deficits, mainly because damaged neurons fail to regenerate after SCI. Schwann cells (SC) play important role in supporting axon regeneration after peripheral nerve injury. Their regenerative potential makes them ideal candidates for use in SCI to support axon regeneration. However, a significant improvement in recovery is seen only when SC are combined with additional therapeutic agents. Administration of such agents often requires multiple injections, which increases chances of inflammation, infection and complicates dosage control. Engineered SC that produce therapeutic agents at the site of SCI can obviate the need for multiple injections. What is currently lacking is an approach that allows to control engineered SC post-transplantation. The objective of this project was to test an optogenetic approach to controlling gene expression in SC. Light in the near-infrared window (NIRW) encompasses the spectrum of 670 to 900 nm. NIRW light penetrates deeply through mammalian tissues and is safe for medical applications. NIRW light represents a non-invasive way of achieving spatio-temporal control over transplanted cells. In this study, we engineered SC stably expressing a NIRW light-responsive adenylyl cyclase, IlaM5. We showed that NIRW irradiation activates expression of a reporter luciferase from a cAMP-dependent promoter. Several fold increase in luciferase levels were observed following a one-hour long irradiation of SC. The activation levels were higher if biliverdin, the chromophore for IlaM5, was added to SC exogenously. This study represents a proof-of-concept that SC can be effectively engineered to respond to NIRW light, which opens opportunities for translational applications of engineered, NIRW light-controlled SC in spinal cord regeneration.