Single Arm Phase Ii Survival Trial Design

Author: Jianrong Wu
Editor: CRC Press
ISBN: 1000421732
File Size: 25,44 MB
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Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software. Key Features: Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion. Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint. Illustrates trial designs by real clinical trial examples Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.
Single-Arm Phase II Survival Trial Design
Language: en
Pages: 273
Authors: Jianrong Wu
Categories: Mathematics
Type: BOOK - Published: 2021-07-19 - Publisher: CRC Press

Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event
Single-Arm Phase II Survival Trial Design
Language: en
Pages: 273
Authors: Jianrong Wu
Categories: Mathematics
Type: BOOK - Published: 2021-08-06 - Publisher: CRC Press

Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event
Randomized Phase II Cancer Clinical Trials
Language: en
Pages: 244
Authors: Sin-Ho Jung
Categories: Mathematics
Type: BOOK - Published: 2013-05-02 - Publisher: CRC Press

In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these
Statistical Design, Monitoring, and Analysis of Clinical Trials
Language: en
Pages: 404
Authors: Weichung Joe Shih, Joseph Aisner
Categories: Medical
Type: BOOK - Published: 2021-10-26 - Publisher: CRC Press

Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors’ courses taught to public health and medical students, residents, and fellows during the past 20 years, the
Statistical Methods for Survival Trial Design
Language: en
Pages: 257
Authors: Jianrong Wu
Categories: Mathematics
Type: BOOK - Published: 2018-06-14 - Publisher: CRC Press

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or