Solid State Properties Of Pharmaceutical Materials

Author: Stephen R. Byrn
Editor: John Wiley & Sons
ISBN: 1118145305
File Size: 27,93 MB
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Solid-State Properties of Pharmaceutical Materials -- Contents -- Preface -- Acknowledgments -- 1 Solid-State Properties and Pharmaceutical Development -- 1.1 Introduction -- 1.2 Solid-State Forms -- 1.3 ICH Q6A Decision Trees -- 1.4 "Big Questions" for Drug Development -- 1.5 Accelerating Drug Development -- 1.6 Solid-State Chemistry in Preformulation and Formulation -- 1.7 Learning Before Doing and Quality by Design -- 1.8 Performance and Stability in Pharmaceutical Development -- 1.9 Moisture Uptake -- 1.10 Solid-State Reactions -- 1.11 Noninteracting Formulations: Physical Characterizations -- References -- 2 Polymorphs -- 2.1 Introduction -- 2.2 How Are Polymorphs Formed? -- 2.3 Structural Aspect of Polymorphs -- 2.3.1 Configurational Polymorphs -- 2.3.2 Conformational Polymorphs -- 2.4 Physical, Chemical, and Mechanical Properties -- 2.4.1 Solubility -- 2.4.2 Chemical Stability -- 2.4.3 Mechanical Properties -- 2.5 Thermodynamic Stability of Polymorphs -- 2.5.1 Monotropy and Enantiotropy -- 2.5.2 Burger and Rambergers Rules -- 2.5.3 vant Hoff Plot -- 2.5.4 DG/Temperature Diagram -- 2.6 Polymorph Conversion -- 2.6.1 Solution-Mediated Transformation -- 2.6.2 Solid-State Conversion -- 2.7 Control of Polymorphs -- 2.8 Polymorph Screening -- 2.9 Polymorph Prediction -- References -- 3 Solvates and Hydrates -- 3.1 Introduction -- 3.2 Pharmaceutical Importance of Hydrates -- 3.3 Classification of Pharmaceutical Hydrates -- 3.4 Water Activity -- 3.5 Stoichiometric Hydrates -- 3.6 Nonstoichiometric Hydrates -- 3.7 Hydration/Dehydration -- 3.8 Preparation and Characterization of Hydrates and Solvates -- References -- 4 Pharmaceutical Salts -- 4.1 Introduction -- 4.2 Importance of Pharmaceutical Salts -- 4.3 Weak Acid, Weak Base, and Salt -- 4.4 pH-Solubility Profiles of Ionizable Compounds
Solid-State Properties of Pharmaceutical Materials
Language: en
Pages: 432
Authors: Stephen R. Byrn, George Zografi, Xiaoming (Sean) Chen
Categories: Science
Type: BOOK - Published: 2017-08-28 - Publisher: John Wiley & Sons

Solid-State Properties of Pharmaceutical Materials -- Contents -- Preface -- Acknowledgments -- 1 Solid-State Properties and Pharmaceutical Development -- 1.1 Introduction -- 1.2 Solid-State Forms -- 1.3 ICH Q6A Decision Trees -- 1.4 "Big Questions" for Drug Development -- 1.5 Accelerating Drug Development -- 1.6 Solid-State Chemistry in Preformulation and
Solid State Properties of Pharmaceutical Materials
Language: en
Pages:
Authors: Stephen R. Byrn, George Zografi, Sean Chen
Categories: Solid dosage forms
Type: BOOK - Published: 2017 - Publisher:

Books about Solid State Properties of Pharmaceutical Materials
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